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Clinical Trials/NCT07553312
NCT07553312
Enrolling By Invitation
Not Applicable

Clinic-Community Bridge-to-Care Initiative: Trauma and Violence Informed Care (TVIC) With Women Survivors of Intimate Partner Violence (IPV) and Living With HIV/AIDS

Johns Hopkins University1 site in 1 country450 target enrollmentStarted: March 17, 2026Last updated:

Overview

Phase
Not Applicable
Status
Enrolling By Invitation
Enrollment
450
Locations
1
Primary Endpoint
Depression as assessed by the PROMIS Depression scale

Overview

Brief Summary

Women living with HIV/AIDS (WLWHA) in Baltimore experience disproportionately high rates of intimate partner violence (IPV), housing instability, and food insecurity, which adversely affect health outcomes. The Bartlett Bridges study is being implemented in partnership with the John G. Bartlett Infectious Diseases Specialty Practice (Bartlett Clinic) located at Johns Hopkins Hospital. The Bartlett Clinic provides comprehensive, compassionate and equitable services for infectious disease prevention, diagnosis and care. The study team will adapt and evaluate a trauma and violence-informed care (TVIC) intervention, called Confidentiality, Universal Education and Empowerment and Support (CUES), enhanced with the evidence-based myPlan safety planning app in the Bartlett Clinic to address IPV, health and safety in partnership with community organizations that provide advocacy, housing and social services. This hybrid effectiveness-implementation trial aims to improve HIV and mental health outcomes, increase safety, reduce health disparities, and identify implementation mechanisms to inform future scale-up and sustainability of the intervention in healthcare settings.

Detailed Description

Objectives Aim 1: Using the ADAPT-ITT framework, the clinic-community partners will collaboratively adapt/design the CUES intervention enhanced with myPlan and connections to community organizations (CUES+) to meet the complex health and safety needs of abused WLWHA. The Hopkins team and members of the investigator's clinic-community advisory board (CAB) will collaborate to adapt and design the CUES+ intervention.

Aim 2: Examine the effectiveness of the CUES+ intervention in reducing health disparities for abused WLWHA. All WLWHA clients will receive CUES+ through the clinic-community partnership. Primary outcomes (ART adherence, missed visits/proportion of visits missed, treatment adherence self-efficacy) and mental health (depression, PTSD) will be measured at baseline, 6-, and 12-months post baseline. The investigators hypothesize IPV(+) WLWHA will have poorer outcomes than IPV(-) WLWHA at baseline. After the CUES+ intervention, outcomes for IPV(+) WLWHA will approach the level of outcomes for IPV(-) WLWHA.

Aim 3: Assess the mechanisms, facilitators, and barriers to implementation of clinic-community CUES+ intervention. Aim 3a: Mechanisms (e.g., safety behaviors/resources, IPV exposure, housing stability, food security) by which CUES+ intervention improves primary outcomes will be examined. The investigators hypothesize the intervention will increase safety behaviors and resources, housing stability and food security and reduce IPV exposure resulting in improvements in primary health outcomes. An understanding of mechanisms will identify clinic-community organizational culture, resources and policies needed to sustain the partnership. Aim 3b: Examine clinic-community-based partners contextual and program factors that facilitate the intervention and are needed to sustain the partnerships. The investigators will also examine barriers and facilitators to the intervention from the perspectives of clinicians and community-based partners to inform future implementation and scale-up.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
Female
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Hopkins Bartlett Clinic patient
  • HIV/AIDS positive
  • Self-identify as female
  • Adult (18 years of age or older)

Exclusion Criteria

  • Not a Hopkins Bartlett Clinic patient
  • HIV/AIDS negative
  • Does not identify as female
  • Under age of 18 years of age
  • Unable to provide informed consent

Arms & Interventions

Women with HIV/AIDS and IPV

Adult women receiving care at Hopkins Bartlett Clinic diagnosed with HIV/AIDS and report past year intimate partner violence (IPV)

Women with HIV/AIDS, no IPV

Adult women receiving care at Hopkins Bartlett Clinic diagnosed with HIV/AIDS, no past year IPV

Outcomes

Primary Outcomes

Depression as assessed by the PROMIS Depression scale

Time Frame: Baseline, 6 and 12 months post baseline

PROMIS Depression 8. Score range 0 to 32; higher score is worse

HIV-related viral load

Time Frame: 12 months post baseline

Obtained from Medical Record. Score range 0-\>100,000; higher scores are worse

PTSD Checklist (PCL-6)

Time Frame: Baseline, 6 and 12 months post-baseline

PCL-6 - 6 items. Score range: 0-24; higher score is worse

Retrospective HIV adherence

Time Frame: Baseline, 6 and 12 months post-baseline

Retrospective Adherence 5-items. Score range 0-15; higher score is worse

HIV Adherence Self-Efficacy

Time Frame: Baseline, 6 and 12 months post-baseline

HIV Adherence Self-Efficacy Scale 13-items. Score range 0-39; higher score is better

Secondary Outcomes

  • Safety Behaviors survey(Baseline, 6 and 12 months post-baseline)
  • Intimate partner violence (IPV) as assessed by the Composite Abuse Scale(Baseline, 6 and 12 months post-baseline)
  • Housing Stability as assessed by the Homelessness Screening Clinical Reminder(Baseline, 6 and 12 months post-baseline)
  • Food security as assessed by the Food Security in the US Survey(Baseline, 6 and 12 months post-baseline)
  • Housing Conditions as assessed by the Property Condition Assessment(Baseline, 6 and 12 months post-baseline)
  • Suicide Behavior(Baseline, 6 and 12 months post-baseline)
  • Health and Well-being as assessed by the PROMIS Global Health Scale(Baseline, 6 and 12 months post baseline)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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