A prospective, randomized clinical trial in split mouth design analyzing the influence of an autologous fibrin matrix (PRF) on wound healing and bone regeneration after osteotomy of displaced and retained third molars
Not Applicable
Recruiting
- Conditions
- Regeneration of extraction socketsK08.1Loss of teeth due to accident, extraction or local periodontal disease
- Registration Number
- DRKS00019229
- Lead Sponsor
- niversitätsklinikum der Goethe-Universität Frankfurt am Main Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients in need of osteotomy of at least two third molars (at least 1 tooth on each side); Patients with informed consent (under age patients with parents approval); Patients at an age of at least 16 years
Exclusion Criteria
Patients younger than 16 years;
Patients with contraindication for surgery;
Patients allergic to necessary medication and/or medical devices;
Patients with chronic medication possibly influencing pain perception and/or inflammation and/or wound healing ;
Immunocompromised persons;
Patients without informed consent;
Pregnant or breast feeding women
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Pain (VAS)<br>- Swelling according to Gabka+Matsumara, measured between 5 reference points
- Secondary Outcome Measures
Name Time Method - wound healing and morbidity<br>- trismus (maximal mouth opening)<br>- post-surgery complications<br>- photo documentation of wound healing