Hepatic insulin resistance and Dopaminergic dysfunction in a Ultra High Risk (UHR) population for Schizophrenia
- Conditions
- delusionpsychosis1001842410039628
- Registration Number
- NL-OMON31345
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Age 18-35
Ultra high risk symptoms for development of psychosis as defined by McGorry et al (2002).
Healthy controls matched for age, sex, BMI, IQ, ethnicity, viceral and subcutanious fat mass.
Exclusion Criteria
Previous psychotic episode
Previous use of antipsychotics, or regular use of cocaine or amphetamins
Type I and II diabetes mellitus
Renal insufficiency
Family history for type II diabetes mellitus.
Familial dyslipidemia
Treatment with drugs which are known to interfere with glucose or lipid metabolism
Alcohol consumption in excess of 3 units per day or in the last 3 days before the clamp
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Glucose productions (suppression)</p><br>
- Secondary Outcome Measures
Name Time Method <p>n.a.</p><br>