Interleukin 20 and Periodontal Tisuue Destruction

Completed

• Conditions: Periodontitis
• Interventions: Other: biochemical analysis

• Registration Number: NCT06091800
• Lead Sponsor: Recep Tayyip Erdogan University

Brief Summary

Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. The aim of this study was to evaluate the effect of IL-20 on periodontal destruction.

In the study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group) and 30 of whom were systemically healthy and had periodontitis (periodontitis group). GCF and serum samples were collected from the participants for biochemical analysis. ELISA method was used to determine IL-20, TNF-α, IL1β/IL-10, RANKL/OPG and MMP8 levels

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-06
• Primary Completion: 2023-03-06
• Study Completion: 2023-06-06
• Status Verified: 2023-10
• Study First Submitted: 2023-10-11
• Study First Submitted QC: 2023-10-18
• Last Update Submitted: 2023-10-18
• Study First Posted: 2023-10-19
• Last Update Posted: 2023-10-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• The following criteria were required for inclusion: being systemically healthy, not smoking, not using antibiotics or systemic corticosteroids within the previous three months, not being pregnant or nursing, not having a chronic inflammatory disease, not receiving periodontal therapy within the previous six months, and possessing at least 20 teeth

Exclusion Criteria

• smoking, using antibiotics or systemic corticosteroids within the previous three months, pregnant, receiving periodontal therapy within the previous six months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
periodontitis group	biochemical analysis	interdental clinical attachment level ≥ 5 mm, probing pocket depth ≥ 6 mm, radiographic bone loss extending to the middle or apical thirds of the root, mid-crest defect, and a history of ≤4 teeth loss of periodontal origin
control group (periodontally healthy)	biochemical analysis	no attachment loss, probing pocket depth ≤ 3 mm, minimal bleeding on probing ≤ 10%, and no radiographic bone loss

Primary Outcome Measures

Name	Time	Method
concentration of biochemical findings in gingival crevicular fluid (GCF)	june 2022-june 2023	IL-20, RANKL, OPG and RANKL/OPG values eveluated in GCF
concentration of biochemical findings in serum	1 year	IL-20, RANKL, OPG, RANKL/OPG, MMP-8, TNF-α, IL-1β, IL-10 and IL-1β/IL-10

Secondary Outcome Measures

Name	Time	Method
value of periodontal clinical parameters were measured in mm	1 year	probing pocket depth (PPD), clinical attachment loss (CAL) of all natural teeth of the patients
value of periodontal clinical parameters	1 year	plaque index (PI) (Silness \& Löe), gingival index (GI) (Silness \& Löe) and bleeding on probing index (BOP) of all natural teeth of the patients

Trial Locations

Locations (1)

Recep Tayyip Erdogan University; 🇹🇷 Rize, Turkey