Effects of Prophylactic Administration of Magnesium Sulfate on the Incidence of Atrial Fibrillation and Chronic Neuropathic Pain After Thoracotomy for Lung Resection.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Incidence of atrial fibrillation
研究概览
简要总结
Atrial fibrillation and chronic neuropathic pain are adverse events occurring after posterolateral thoracotomy for lung resection. The continuous application of magnesium sulphate may have a prophylactic effect. The investigators record the incidence of atrial fibrillation during a seven day period after thoracotomy as well as the incidence of chronic neuropathic pain during a three months period, comparing one group with a continuous application of magnesium sulphate against one group without magnesium sulphate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years or older
- •posterolateral thoracotomy for lung parenchyma resection
- •informed consent
排除标准
- •hypersensitivity for magnesium sulphate
- •pre-existing atrial fibrillation
- •participation in another trial
- •pregnancy or breastfeeding
研究组 & 干预措施
Magnesium sulphate
The patients in this group underwent general anaesthesia with total intravenous anesthesia containing Remifentanyl (0,3 mg/kg ideal body weight/h), Propofol (4 mg/kg ideal body weight/h) and Atracurium.
They also received 40mg/kg ideal body weight magnesium sulphate by bolus injection before the operation started, followed by a continuous application of 10mg/kg ideal body weight/hour for 24 hours.
干预措施: Magnesium sulphate (Drug)
结局指标
主要结局
Incidence of atrial fibrillation
时间窗: Up to 168 hours after operation
The incidence of atrial fibrillation was recorded using a 12 lead ECG for a period of 7 days after operation
次要结局
- Chronic neuropathic pain(Three months)