Blastocyst Culture Using Time-lapse in Good Prognosis IVF Patients and Elective Single Embryo Transfer

Not Applicable

Terminated

• Conditions: Infertility
• Interventions: Device: Embryoscope

• Registration Number: NCT01773603
• Lead Sponsor: Dr. Murat Çetinkaya

Brief Summary

Choosing the best embryo for transfer has become the major challenge in in vitro fertilization (IVF). Morphology alone is obviously not enough and time-lapse incubation has added embryo development kinetics as another selection criterion.

This study was designed to select for the top blastocyst to be replaced, while increasing the pregnancy chance, with the local legislation regulating the number of embryos to be transferred and to establish a morphokinetic standard to be used in our clinical setting.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-12
• Primary Completion: 2012-06
• Study Completion: 2012-07
• Status Verified: 2013-01
• Study First Submitted: 2013-01-18
• Study First Submitted QC: 2013-01-18
• Last Update Submitted: 2013-01-18
• Study First Posted: 2013-01-23
• Last Update Posted: 2013-01-23

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

• patients in their first or second ART treatment cycle
• no recurrent spontaneous abortions
• age<35 years
• BMI<28 kg/m2
• ≥8 oocytes retrieved

Exclusion Criteria

• severe endometriosis
• polycystic ovary syndrome
• hydrosalpynx
• uterine pathology
• severe male factor (presenting less than 5 million motile sperm cells in total in the ejaculate)
• very severe morphological sperm defects (mainly globozoospermic or macrocephalic samples)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Embryoscope	Embryoscope	Five-day embryo culture in embryoscope which is an incubator with a built-in camera

Primary Outcome Measures

Name	Time	Method
Blastocyst formation rate	5th day of embryonic development

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate	7th week of pregnancy	Clinical pregnancy was defined as the presence of a gestational sac detected on ultrasound 3 weeks after the first βhCG test, which was performed 14 days after oocyte retrieval.

Trial Locations

Locations (1)

Sisli Memorial Hospital; 🇹🇷 Istanbul, Turkey