Effects of supplementation with vitamin D on clinical outcomes, quality of life, anxiety, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid and ratio of 5-HIAA/ 5-HT in Patient with irritable bowel syndrome the predominant form diarrhea

Vice Chancellor for Research,Iran University of Medical Sciences0 个研究点目标入组 88 人开始时间: 待定最近更新: 2018年2月22日

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•Inclusion criteria for the study: aged between 18 and 60 years; suffering from irritable bowel syndrome ROME III criteria and completed the questionnaires; their disease severity score is between 175 and 300; BMI Between 18.5 to 34.9; a resident of Tehran; have diarrhea-predominant irritable bowel syndrome with form.
•Non-inclusion criteria: pregnant women or nursing mothers; a history of gastrointestinal diseases, including IBD, colorectal cancer and...; Gastrointestinal diseases such as celiac disease, is an infection of the gastrointestinal tract and ...; Abdominal surgery or radiation therapy, cholecystectomy, etc. (If your gallbladder is removed, the probability malabsorption of fat and vitamin D absorption.); The use of vitamin D supplements, six months before; Use of now any type of supplement or 3 months; probiotic supplement use; Antidepressants uses (Including serotonin receptor antagonists, tricyclic antidepressants, selective serotonin reuptake inhibitors, etc.); High-dose alcohol and caffeine 24 hours before the test; smoking 48 hours before the test
•Exclusion criteria: Create any abnormal reactions to supplements; gastrointestinal bleeding; blood in the stool; rapid weight loss ; the level of vitamin D normal (above 30 nmol / L); less than 80 percent of supplements ; no intention to continue cooperation

发起方

Vice Chancellor for Research,Iran University of Medical Sciences