The effect of vitamin D supplementation on patients with irritable bowel syndrome

Not Applicable

Completed

Conditions: irritable bowel syndrome.
Irritable bowel syndrome with diarrhoea

Registration Number: IRCT201701162709N42

Lead Sponsor: Vice Chancellor for Research,Iran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 88

Inclusion Criteria

Inclusion criteria for the study: aged between 18 and 60 years; suffering from irritable bowel syndrome ROME III criteria and completed the questionnaires; their disease severity score is between 175 and 300; BMI Between 18.5 to 34.9; a resident of Tehran; have diarrhea-predominant irritable bowel syndrome with form.
Non-inclusion criteria: pregnant women or nursing mothers; a history of gastrointestinal diseases, including IBD, colorectal cancer and...; Gastrointestinal diseases such as celiac disease, is an infection of the gastrointestinal tract and ...; Abdominal surgery or radiation therapy, cholecystectomy, etc. (If your gallbladder is removed, the probability malabsorption of fat and vitamin D absorption.); The use of vitamin D supplements, six months before; Use of now any type of supplement or 3 months; probiotic supplement use; Antidepressants uses (Including serotonin receptor antagonists, tricyclic antidepressants, selective serotonin reuptake inhibitors, etc.); High-dose alcohol and caffeine 24 hours before the test; smoking 48 hours before the test
Exclusion criteria: Create any abnormal reactions to supplements; gastrointestinal bleeding; blood in the stool; rapid weight loss ; the level of vitamin D normal (above 30 nmol / L); less than 80 percent of supplements ; no intention to continue cooperation

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of life. Timepoint: Before and after 3 months of intervention. Method of measurement: Irritable Bowel Syndrome Quality of Life Questionnaire.;Severity of Clinical symptoms. Timepoint: Before and after 3 months of intervention. Method of measurement: IBS symptom severity questionnaire.;Clinical signs. Timepoint: Before and after 3 months of intervention. Method of measurement: ROME IV questionnaire and World Gastroenterology Organization questionnaire for the diagnosis of irritable bowel syndrome.

Secondary Outcome Measures

Name	Time	Method
Anxiety. Timepoint: Before and after 3 months of intervention. Method of measurement: Hospital Anxiety and Depression Scale(HADS).;Serum levels of serotonin. Timepoint: Before and after 3 months of intervention. Method of measurement: Blood serum in terms of nmol /L.;Serum levels of 5-hydroxy indole acetic acid. Timepoint: Before and after 3 months of intervention. Method of measurement: Blood serum in terms of nmol /L.