Modeling Treated Recovery From Aphasia

Not Applicable

Completed

• Conditions: Aphasia, Mixed; Aphasia, Expressive; Aphasia, Anomic; Aphasia, Broca; Aphasia, Jargon; Stroke; Stroke, Ischemic; Aphasia; Aphasia, Global; Aphasia, Conduction
• Interventions: Behavioral: Semantically focused treatment; Behavioral: Phonologically focused treatment

• Registration Number: NCT03416738
• Lead Sponsor: University of South Carolina

Brief Summary

Stroke is the leading cause of adult disability in the United States, and aphasia is common following a stroke to the left hemisphere of the brain. Aphasia therapy can improve aphasia recover; however, very little is known about how different patients respond to different types of treatments.

The purpose of this study is to understand how the following factors influence an individual's response to aphasia treatment: 1) biographical factors (e.g., age, education, gender), 2) post-stroke cognitive/linguistic abilities and learning potential, and 3) the location and extent of post-stroke brain damage. We are also interested in understanding the kinds of treatment materials that should be emphasized in speech/language treatment.

Overall, the goal of the current research is to inform the clinical management of post-stroke aphasia by identifying factors that can predict how an individual will respond to different treatment methods.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-02
• Study First Submitted: 2018-01-23
• Study First Submitted QC: 2018-01-30
• Study First Posted: 2018-01-31
• Primary Completion: 2021-05-30
• Study Completion: 2021-05-30
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-27
• Last Update Posted: 2022-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 127

Inclusion Criteria

• Experienced a left hemisphere ischemic or hemorrhagic stroke At least 12 months post-stroke
• Primarily English speaker for the past 20 years
• Ability to provide informed written or verbal consent MRI-compatible (e.g., no metal implants, not claustrophobic)

Exclusion Criteria

• History of a right hemisphere stroke (Bilateral stroke)
• Clinically reported history of dementia, alcohol abuse, psychiatric disorder, traumatic brain injury, or extensive visual acuity or visual-spatial problems
• Severely limited speech production and/or auditory comprehension that interferes with adequate participation in the therapy provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Semantically focused treatment	Semantically focused treatment	This treatment will focus on improving word finding and comprehension of information.
Phonologically focused treatment	Phonologically focused treatment	This treatment will focus on training speech sound production, targeting overall production abilities.

Primary Outcome Measures

Name	Time	Method
Philadelphia Naming Test	6 months	Assesses the ability to name functional objects

Trial Locations

Locations (2)

University of South Carolina; 🇺🇸 Columbia, South Carolina, United States

Medical University of South Carolina; 🇺🇸 Charleston, South Carolina, United States