Effect of memantin on cognitive performance in patient under electroconvolsive therpy (clinical trial)

Phase 1

• Conditions: Cognitive impairment.

• Registration Number: IRCT20170606034348N3
• Lead Sponsor: Babol University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 23 April 2019

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

In this clinical trial, 60 patients over the age of 18 and under the age of 60 with bipolar disorder psychiatric illnesses will be admitted to the ECT since the beginning of the year 1396-97.All patients will undergo a full psychiatric assessment and patient disorder is recorded based on DSM-V.

Exclusion Criteria

Age outcomes aged less than 18 years and over 60 years of age, alcohol dependence or drug and drug addiction (except nicotine and caffeine) within 3 months of admission, confirmed kidney disease, epilepsy, back Mental retardation, cognitive impairments such as delirium and dementia, history of memantine use in the past 3 months before entering the study, patients who are unable to perform tests due to distraction , gastrointestinal disturbances and memantine susceptibility, and during Studying or suffering from intolerance to increasing the dose of memantine, as well as patients who receive more than 6 ECT sessions, are excluded be.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The cognitive ability of the patients will be measured 24 hours before and 24 hours after the ECT session 6, as well as one month after the completion of the ECT using the MMSE (Mini Mental Status Examination) and the Aden Brook Cognitive Examination Test. We will use the MMSE Iranian version in this study. Timepoint: 24 hours before and 24 hours after the 6th session of the ECT, as well as one month after the completion of the ECT. Method of measurement: Eden Brook MMSE (Mini Mental Status Examination).

Secondary Outcome Measures

Name	Time	Method
As well as one month after the completion of the ECT using the MMSE (Mini Mental Status Examination) and the Aden Brook Cognitive Examination Test. We will use the MMSE Iranian version in this study. Timepoint: One month after the completion of the ECT. Method of measurement: In this research we will use the Iranian version of MMSE and Eden Brooke.