A SURVEY STUDY TO FIND OUT THE ETIOLOGICAL FACTOR OF PAAMA ATOPIC DERMATITIS
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 278
- 试验地点
- 1
- 主要终点
- Insights into the epidemiology, triggers, and management practices of atopic dermatitis in
研究概览
简要总结
Introduction
In Ayurvedic texts, mainly the skin disorders are included under the Kuhstha. Kushtha are of two types one is mahakuhstha and another one is kshudra kushtha. Paama is one among Kshudra Kustha, having pitta and kapha dosha as dominant dosha according to Acharya Charaka. Lakshana told are skin lesions having severe itching with many blisters with Shweta, Aruna, Shyava varna1’ 2. Atopic dermatitis, also known as atopic dermatitis, is a chronic inflammatory skin disorder affecting millions worldwide3. Atopic dermatitis (AD) is an atopic dermatitistous eruption that is itchy, recurrent, and sym- metric. It generally begins early in life (3 months of age or so), follows periods of remissions and exacerbation, and usually resolves by the age of 15 years. Elevated IgE levels are the most consistent immune defect4. Despite various treatment options, there’s a persistent need for novel therapies. Paama, a traditional medicinal remedy, has shown promise in anecdotal evidence. 1-Chloro-2,4-dinitrobenzene (DNCB) is a chemical substance that causes chronic contact dermatitis and is widely used in human studies of AD. In this study, BALB/c mice with DNCB-induced AD are used. When DNCB is topically applied to mice, it causes dermatopathy similar to symptoms of AD, such as an increased IgE expression, inflammatory cytokines, edema and itching5. To relieve itching, medicines in the form of local application as lepa is more suitable. NIARG-CT-PPL is having shatadhouta ghrita as its base and NIARG-CT-PTL is having Sarshapa taila as base which will decrease the dryness, itching. This study aims to scientifically validate the therapeutic potential of paama in managing atopic dermatitis.
HYPOTHESIS
Null Hypothesis:There is no association of Etiopathological factors with Paama (atopic dermatitis].
Alternative Hypothesis (H1) – There is association of Etiopathological factors with Paama (atopic dermatitis).
AIM :- To elucidate the etiopathological factors of paama (Atopic dermatitis) through survey analysis.
OBJECTIVES :- To conduct a survey analysis to gather insights into the etiology, prevalence, and management practices of atopic dermatitis in human subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient with classical sign and symptoms of Paama (atopic dermatitis) like skin lesions having severe itching with many blisters with Shwetha, Aruna, Shyava varna.
- •Patients of either sex and age greater than 18-60 years.
排除标准
- •Individuals with a history of other dermatological conditions (e.g., psoriasis, eczema) besides atopic dermatitis.
- •Participants who are currently undergoing treatment with systemic immunosuppressive medications or biologic therapies for any medical condition.
- •Individuals with a history of allergic reactions or adverse events to topical medications or skincare products.
- •Participants who are unable to provide informed consent or complete the survey due to cognitive impairment or language barriers.
- •Subjects below the age of 18 years, unless specific pediatric criteria are included in the survey design.
- •Participants who do not meet the predefined inclusion criteria specified in the survey protocol.
结局指标
主要结局
Insights into the epidemiology, triggers, and management practices of atopic dermatitis in
时间窗: at the end of study
human subjects.
时间窗: at the end of study
次要结局
- To find out causative factors of PAAMA (atopic dermatitis)(at the end of study)
研究者
Seema Bai
National Institute of Ayurveda jaipur