Phenotype/Genotype Correlations in Movement Disorders
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,500
- 试验地点
- 1
- 主要终点
- The primary outcome measure is the phenotypic and genotypic characterizations of patients and family members with movement disorders.
研究概览
简要总结
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.
详细描述
Objective: The primary objective of this study is to perform phenotypic and genotypic characterizations of patients and family members with a known or suspected diagnosis of a movement disorder and screen for eligibility to participate in other movement disorder related protocols:
- 14-N-0086 Deep brain stimulation therapy in movement disorders
- 11-N-0211 Deep brain stimulation surgery for movement disorders
- 000865: Natural history of movement disorders
- 00-N-0043: Clinical and molecular manifestations of inherited neurologic disorders
- 03-AG-N-329 (NIA): The genetic characterization of movement disorders and dementias
- 20M0082 Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease; Institute (NIMH)
The secondary goals of this protocol are to learn more about genetic causes of movement disorders and their phenotypic associations; identify patients and families with inherited movement disorders; evaluate disease manifestations to establish an accurate clinical diagnosis; and to investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with well-documented genealogical records are especially valuable. The study will also assess a series of exploratory peripheral biomarkers, including, but not limited to, those delineated by DNA, RNA, protein, and/or metabolite alterations in an effort to more accurately predict those with, or at risk of having, the specific neurological disease.
Study population: Subjects older than 2 years old with movement disorders and their family members will be enrolled. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlations. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms and/or peripheral bio-signatures involved in a particular disorder.
Design:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •INCLUSION CRITERIA:
- •Individuals with suspected movement disorders
- •Family members of movement disorders patients
- •Ability to give informed consent or have a legally authorized representative able to give consent (for adults without consent capacity) or parent/guardian able to provide informed consent (for a child)
- •If unable to give informed consent, ability to give assent (for children or adults without consent capacity)
- •NIH Employees can participate in this study if they meet eligibility.
排除标准
- •Pregnant women
- •Children less than 2 years of age
- •Employees of the Parkinson's Disease Clinic, NINDS
- •Exclusion criteria for MRI
- •Presence of metal in subject s body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if subject was a welder or metal worker, since small metal fragments in the eye may be present.
- •Subject is uncomfortable in small closed spaces (have claustrophobia) so that they would feel uncomfortable in the MRI machine.
- •Unable to lie comfortably on back for up to 1 hour
- •Under 12 years of age
- •There is no general exclusion for NIH employees.
研究组 & 干预措施
Patients 2
Patients with disease of unknown or incomplete genetic characterization.
Patients 1
Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlations.
Subjects
Subjects older than 2 years old with movement disorders and their family members
结局指标
主要结局
The primary outcome measure is the phenotypic and genotypic characterizations of patients and family members with movement disorders.
时间窗: 10 Years
Characterizations to determine their eligibility for inclusion in other NIH protocols.
次要结局
- Identification of disease-specific biomarkers in stem cells derived from patient peripheral blood mononuclear cells or fibroblast lines(Study end)
- Identification of new genes and/or peripheral blood biomarkers associated with movement disorders(Study end)
- Identification of new genes and/or peripheral blood biomarkers associated with movement disorders.(Study end)
- Establishment of a clinical diagnosis (when possible)(Study end)
- Referral of patients and/or family members for participation in other NIH studies(Study end)