Oxidative stRess drIver Of male iNfertility: ORION study

Completed

• Conditions: male infertility; 10038612

• Registration Number: NL-OMON49093
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
males of couples visiting the Center of Reproductive medicine at the UMCG
between 18-55 years old.

Exclusion Criteria

* Males who receive(d) chemo- and/or radiotherapy, use(d) testosterone
suppletion and/or anabolic steroids
* Males who have an abnormal SA due to genetic causes.
* Semen analysis with round cells >2x106 /ml (as marker for infection)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter will be free thiols in patients with<br /><br>oligo-asthenospermia and patients with normospermia. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Concomitant measurable antioxidants.<br /><br>General health parameters:<br /><br>- BMI<br /><br>- Comorbidities<br /><br>- Medication<br /><br>- Level of degree<br /><br><br /><br>Lifestyle parameters:<br /><br>- Diet<br /><br>- Physical activity<br /><br>- Smoking<br /><br>- Illicit drug use<br /><br>- Toxic exposure at work</p><br>