Mother-infant Microbiota Transmission and Its Link to the Health of the Baby
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20,000
- 试验地点
- 1
- 主要终点
- Develop a 100,000 pair of mother-baby longitudinal cohort
研究概览
简要总结
The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function. Dysbiosis of gut microbiota has been linked with obesity, hyperglycemia, hyperlipidemia, inflammatory bowel disease and other chronic inflammatory diseases. Gut microbiota is affected by host genetic markup, diet and life style; and therefore varied by human races and geographical locations.
The development of gut microbiota starts before birth. The infant's microbiome can impact on human health in later life. The microbiome of pregnant women are associated with early-life microbiota of their offspring as well as growth, neurodevelopment and the development of allergic and neurocognitive disorders.
Early childhood, when the microbiota is less mature and more malleable, is a golden age for microbiota manipulation to prevent disease. Studying microbiota at this golden age also allow us to dissect the development of a faulty microbiota and identify therapeutic targets to reverse it and cure diseases that are already developed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being pregnant
- •Plan to give birth in local hospital
- •Competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent)
- •Plan to stay in the same local area for at least 7 years post-delivery
排除标准
- •New Born Baby Inclusion Criteria
- •Be a new born baby of an enrolled pregnant woman
- •One of the parents or legal guardian is competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) Exclusion Criteria: No
- •Father of new born baby Inclusion Criteria
- •Biological father of an enrolled new born baby
- •Competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) Exclusion Criteria: No
结局指标
主要结局
Develop a 100,000 pair of mother-baby longitudinal cohort
时间窗: 8 year
Set up a large scale database to collect data such as comprehensive clinical data, such as mother's and father's demographic and clinical information (e.g. age, weight, gender, family medical history, dietary, drug usage etc.)
次要结局
- Seize the golden period of early life for prevention of human diseases(8 year)
- Dissect the important microbiome that maintain health(8 year)
研究者
Francis KL Chan
Professor
Chinese University of Hong Kong