Effect of Esophageal Contractile Reserve on Changes in Esophageal Motility and Symptoms After Anti-reflux Surgery in Patients With Gastroesophageal Reflux Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Effect of changes in oesophageal motility after anti-reflux surgery compared to pre-surgery
研究概览
简要总结
rapid swallow (MRS) can assess the contractile reserve capacity of the oesophageal body and identify and diagnose oesophageal motility disorders, but the impact of preoperative oesophageal reserve capacity on postoperative symptoms and motility in patients with GERD remains unclear. The aim of this study was to assess the effect of pre-operative oesophageal reserve capacity on post-reflux symptoms and motility in patients with GERD by using a high-resolution oesophageal manometry-based provocation test, MRS, to track pre-operative ineffective oesophageal motility (IEM).
详细描述
Lower oesophageal sphincter relaxation is an important cause of GERD and ineffective oesophageal motility may be associated with GERD, but the mechanism of oesophageal corporal motility disorders is unclear. High-resolution manometry (HRM) has shown to be more accurate than conventional manometry in assessing oesophageal motility, and can provide guidance for GERD surgery. The aim was to conduct a cohort study to investigate the yu'h of patients with preoperative esophageal motility disorders with or without esophageal reserve, based on the assessment of esophageal motility by high-resolution esophageal manometry to follow up changes in esophageal motility and symptoms in patients after anti-reflux surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 18 years old
- •Patients to be treated surgically for gastroesophageal reflux disease
- •Ineffective esophageal motility diagnosed by high resolution esophageal manometry according to Chicago Classification version 4.0
- •Obtaining Informed Consent
排除标准
- •Previous other upper gastrointestinal surgery
- •Pregnant women and other people with contraindications to surgery and tests
- •Other specifically defined esophageal motility disorders, such as nutcracker esophagus
结局指标
主要结局
Effect of changes in oesophageal motility after anti-reflux surgery compared to pre-surgery
时间窗: 2 year follow-up after anti-reflux surgery
Using high resolution manometry to assess changes in oesophageal motility after anti-reflux surgery, compared to pre-surgery.
次要结局
- Effect of changes of post-anti-reflux surgery symptoms(2 year follow-up after anti-reflux surgery)
研究者
Yanqing Li
Vice-President
Shandong University