MedPath

Combination Chemotherapy in Treating Patients With Stage I, II, or IIIA Non-small Cell Lung Cancer That Has Been Surgically Removed

Phase 3
Conditions
Lung Cancer
Registration Number
NCT00003053
Lead Sponsor
European Institute of Oncology
Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

PURPOSE: Randomized phase III trial to compare cisplatin and etoposide with no chemotherapy in treating patients who have stage I, stage II, or stage IIIA non-small cell lung cancer that has been surgically removed.

Detailed Description

OBJECTIVES:

* Assess the efficacy of the combination of cisplatin and etoposide after radical surgery in prolonging the relapse free and overall survival for stages I, II, and IIIA non-small cell lung cancer.

OUTLINE: This a randomized study (treatment vs no treatment). Patients are stratified according to sex and to stage of disease (I vs II vs IIIA).

Patient receives cisplatin and etoposide on days 1-3, every 28 days, for 3 cycles. Patient may receive radiation therapy after surgery at the discretion of the physician.

PROJECTED ACCRUAL: Approximately 750 patients will be accrued over 3 years.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
750
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (85)

Ospedale San Filippo Neri

🇮🇹

Rome, Italy

Universita Degli Studi di Bari Policlinico

🇮🇹

Bari, Italy

Ospedale Oncologico A. Businco

🇮🇹

Cagliari, Italy

Ospedale Santa Croce

🇮🇹

Moncalieri, Italy

Universita Degli Studi di Firenze - Policlin. di Careggi

🇮🇹

Firenze (Florence), Italy

Ospedale Galliera Oncologia

🇮🇹

Genova (Genoa), Italy

Ospedale Alessandro Manzoni

🇮🇹

Lecco, Italy

Ospedale Maggiore Lodi

🇮🇹

Lodi, Italy

Ospedale Umberto I

🇮🇹

Lugo DI Romagna, Italy

Ospedale Di Predabissi Melegnano

🇮🇹

Melegnano, Italy

Ospedale Vincenzo Monaldi

🇮🇹

Napoli, Italy

Ospedale Civile Negrar

🇮🇹

Negrar, Italy

University of Padua

🇮🇹

Padua, Italy

Istituti Fisioterapici Ospitalieri - Roma

🇮🇹

Rome, Italy

Clinica Universita

🇮🇹

Torino, Italy

George Papanicolaou General Hospital

🇬🇷

Thessaloniki, Greece

Ospedale Sant Anna

🇮🇹

Como, Italy

Ospedale Bassini

🇮🇹

Balsamo Cinisello, Italy

Ospedale Valduce

🇮🇹

Como, Italy

Spedali Civili

🇮🇹

Brescia, Italy

Ospedale San Michele

🇮🇹

Cagliari, Italy

Cattedra di Oncologia Medica - Universita degli Studi di Cagliari

🇮🇹

Cagliari, Italy

Ospedale Civile Cosenza

🇮🇹

Cosenza, Italy

Ospedale Di Conselice

🇮🇹

Conselice, Italy

Ospedale Maggiore Crema

🇮🇹

Crema, Italy

Policlinico di Careggi

🇮🇹

Firenze (Florence), Italy

Universita di Ferrara

🇮🇹

Ferrara, Italy

Ospedale Civile Feltre

🇮🇹

Feltre, Italy

Ospedale San Martino/Cliniche Universitarie Convenzionate

🇮🇹

Genoa (Genova), Italy

Ospedale Di Gorgonzola

🇮🇹

Gorgonzola, Italy

U.S.L. 10 Villa Ognissanti

🇮🇹

Firenze, Italy

Istituto Nazionale per la Ricerca sul Cancro

🇮🇹

Genoa (Genova), Italy

Ospedale Legnago USSL 21

🇮🇹

Legnago, Italy

U.S.S.L. 72 Magenta

🇮🇹

Magenta, Italy

Carlo Poma Hospital

🇮🇹

Mantova, Italy

Azienda USSL NO 8

🇮🇹

Merate, Italy

Instituto Di Oncologia

🇮🇹

Messina, Italy

Ospedale Civile Umberto I

🇮🇹

Mestre, Italy

Ospedale San Carlo Borromeo

🇮🇹

Milano (Milan), Italy

Ospedale Maggiore Ca'Granda

🇮🇹

Milano (Milan), Italy

Ospedale Luigi Sacco

🇮🇹

Milano (Milan), Italy

Ospedale San Giuseppe

🇮🇹

Milano, Italy

Consorzio Provinciale Antitubercolare

🇮🇹

Milano, Italy

Istituto Di Science Biomediche San Paolo

🇮🇹

Milano, Italy

Casa Di Cura San Ambrogio

🇮🇹

Milano, Italy

Istituto Scientifico H.San Raffaele

🇮🇹

Milano, Italy

Nuovo Ospedale San Gerardo

🇮🇹

Monza, Italy

Ospedale Civile Asilo Vittoria

🇮🇹

Mortara, Italy

Federico II University Medical School

🇮🇹

Naples (Napoli), Italy

Istituto Nazionale per lo Studio e la Cura dei Tumori

🇮🇹

Naples, Italy

Istituto Tumori/Fondazione Pascale

🇮🇹

Naples (Napoli), Italy

Ospedale C. Ascalesi

🇮🇹

Napoli, Italy

Azienda Ospedaliera di Padova

🇮🇹

Padova (Padua), Italy

Ospedale Civico E Benefratelli

🇮🇹

Palermo, Italy

Ospedale Silvestrini

🇮🇹

Perugia, Italy

Ospedale Maggiore Parma

🇮🇹

Parma, Italy

Ospedale Agnelli

🇮🇹

Pinerolo, Italy

Ospedale Torrette University Ancona

🇮🇹

Parma, Italy

Ospedale Sta. Maria Delle Croci

🇮🇹

Ravenna, Italy

Azienda Ospedaliera

🇮🇹

Reggio Emilia, Italy

Ospedale Civile Rho

🇮🇹

Rho, Italy

Ospedale Carlo Forlanini

🇮🇹

Rome, Italy

Azienda Policlinico Umberto Primo

🇮🇹

Rome, Italy

Ospedale S. Camillo-Forlanini

🇮🇹

Rome, Italy

Policlinico A. Gemelli - Universita Cattolica del Sacro Cuore

🇮🇹

Rome, Italy

Policlinico Militare Celio

🇮🇹

Rome, Italy

ASL NO. 1 Imperiese

🇮🇹

San Remo, Italy

Ospedale Generale Prov. Boldrini

🇮🇹

Thiene, Italy

Dispensario Igiene Sociale

🇮🇹

Toino, Italy

Consorzio Mario Negri Sud

🇮🇹

Santa Maria Imbaro, Italy

Azienda USSL No 4

🇮🇹

Saronno, Italy

Azienda Ospedaliera S. Maria

🇮🇹

Terni, Italy

Istituto Clinica Medica

🇮🇹

Sassari, Italy

Ospedale Sesto San Giovanni

🇮🇹

Sesto San Giovanni, Italy

Ospedale San Isidoro

🇮🇹

Trescore Balneario, Italy

Universita di Torino

🇮🇹

Torino, Italy

Ospedale S. Chiara

🇮🇹

Trento, Italy

Ospedale General Regional Ca Foncello

🇮🇹

Treviso, Italy

Ospedale Maggiore dell' Universita

🇮🇹

Trieste, Italy

Ospedale Cattinara

🇮🇹

Trieste, Italy

Cattedra di Immunologia Clinica

🇮🇹

Turin (TO), Italy

Universita Degli Studi di Udine

🇮🇹

Udine, Italy

Casa di Cura S. Maria

🇮🇹

Varese, Italy

Ospedale San Bortolo

🇮🇹

Vicenza, Italy

Inha University Hospital

🇰🇷

Incheon, Korea, Republic of

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