NCT00696722已完成2 期
Influence of Atazanavir Treatment on Endothelial Dysfunction, Vascular Inflammation and Heme Oxygenase Activity in Type 2 Diabetes Mellitus
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Acetylcholine induced vasodilation
研究概览
简要总结
The purpose of this study is to determine whether atazanavir use is of influence on the endothelial dysfunction associated with type 2 diabetes mellitus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
1
Experimental
Placebo treatment first, atazanavir treatment second
干预措施: placebo + atazanavir (Drug)
2
Experimental
Atazanavir treatment first, placebo treatment second
干预措施: atazanavir + placebo (Drug)
结局指标
主要结局
Acetylcholine induced vasodilation
时间窗: following a 4 day treatment with either placebo or atazanavir
次要结局
- assessment of vascular inflammation by determination of adhesion molecule levels(following a 4 day treatment with either placebo or atazanavir)
- heme oxygenase expression and activity(following a 4 day treatment with either placebo or atazanavir)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
4 期
Effect of Atazanavir on Endothelial Function in HIV-Infected PatientsDyslipidemiaHIV InfectionsNCT00447070Foundation for Cardiovascular Research, Zurich50
已完成
2 期
Atazanavir and Endothelial Function in Older HIV PatientsHIVNCT03019783Brigham and Women's Hospital60
终止
4 期
Effects of Etanercept on the Heart, Veins and Thickness of Certain Major Arteries In Ankylosing Spondylitis PatientsAnkylosing SpondylitisNCT00910273Pfizer34
已完成
1 期
The Effect of Lopinavir/Ritonavir on Endothelial FunctionHealthyNCT00076414National Institutes of Health Clinical Center (CC)30
已完成
2 期
Role of Neuraminidase Activity on Endothelial Dysfunction in Type 2 DiabetesDiabetes Mellitus, Type 2NCT04867707University of Missouri-Columbia14