Health, Perception, Practices, Relations and Social Inequalities in the General Population During the Covid-19 Crisis - Serology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 96,883
- 试验地点
- 1
- 主要终点
- Cumulative incidence of SARS-Cov2 infection in the general population.
研究概览
简要总结
This study aims to quantify and follow the cumulative incidence of SARS-CoV-2 infection in the French population using serological tests and to assess the determinants of infection from Constances, E3N-E4N, ELFE-Epipage 2 and NutriNet-Santé cohorts.
详细描述
The primary objective is to assess the cumulative incidence of infection in the general population using dried blood spot sampling.
The secondary objectives are:
- To identify factors associated with a positive SARS-CoV-2 infection (positive serology) and to characterize the durability of the serological response to SARS-CoV-2
- To identify associations of symptoms predictive of a SARS-CoV-2 infection
- To estimate the health care use associated with a SARS-CoV-2 infection
- To estimate the fraction of sub-clinical infections or infections not captured by the healthcare system;
- To study the acceptability of a mass anti-SARS-CoV-2 serological testing and the impact of its result, linked with social inequalities in health;
- To estimate the individual and collective impact of containment and other preventive measures on the risk of SARS-CoV-2 infection;
- To study the impact of social and territorial inequalities on seroprevalence levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non applicable, already enrolled in the cohorts
排除标准
- •non applicable
研究组 & 干预措施
SAPRIS-SERO
SAPRIS-SERO enrolls participants from cohorts entitled: Constances, E3N-E4N, ELFE, Epipage 2 and NutriNet-Santé.
干预措施: Non applicable (Biological)
结局指标
主要结局
Cumulative incidence of SARS-Cov2 infection in the general population.
时间窗: 8 months
Simple and corrected estimate of the number of seropositive individuals/number of individuals at risk in different strata, based on weighting and calibration and taking into account the random cohort effect.
次要结局
- Rate of use of care (medical care, hospitalization, center 15) linked to the occurrence of symptoms suggestive of a SARS-Cov2 infection, and share attributable to the infection(8 months)
- Strengths of associations between socio-behavioral factors and level of seroprevalence(8 months)
- Proportion of infections without reported or pauci-symptomatic symptoms and their epidemiological and social determinants(8 months)
- Proportion and intensity of use of barrier measures (hydroalcoholic gel, mask, social distancing, description of outings / reasons, duration, frequency) and association with the level of seroprevalence(8 months)
- Maintenance over time of the acquisition of anti-SARS-Cov2 antibodies(8 months)
- Proportion of tests proposed, accepted, performed, based on social and demographic characteristics(8 months)