Evaluation of the effect of Elaeagnus angustifolia alone and in combination with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis

Not Applicable

• Conditions: knee osteoarthritis.; Other primary gonarthrosis

• Registration Number: IRCT2015072123282N1
• Lead Sponsor: Barij Essence Pharmaceutical Company

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

age of 40 - 80 years; Osteoarthritis of at least one knee for at least 6 months based on the diagnostic criteria of American College of Rheumatology (ACR); Pain score > 40 mm based on the visual analogue scale (VAS); CRP serum level < 10 mg/dL; LPFI (Lequesne Pain and Function Index) score > 7; Grade 2 or 3 of Kellgren-Laurence scale in knee radiography within the past 6 months

Exclusion criteria: Dysfunction of either liver, kidneys, or cardiovascular system or malignancy; Use of intra-articular glucocorticoids within the past 3 months; Use of intra-articular sodium hyaluronate within the past 6 months; Use of systemic glucocorticoids (either oral or parenteral) within the past 3 months; Having other osteoarticular disorders (e.g., rheumatoid arthritis and gout); Uncontrolled hypertension (> 140/90 mm Hg); Increased ESR; Having gastric or duodenal ulcers (based on the medical history); Sensitivity to the intervention drug; Being candidate for arthroplasty surgery; Not use of the intervention drug for more than one week; Knee arthroscopy within the past 3 months; Illiteracy

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
equesne's Pain and Function Index (LPFI). Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: Questionnaire.;Visual analogue scale (VAS). Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: scoring on the scale.;Patient global assessment (PGA). Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: scoring on the scale.

Secondary Outcome Measures

Name	Time	Method
Adverse effects. Timepoint: during the intervention. Method of measurement: patient report.