Comparing the Prognostic Value of Neutrophil-lymphocyte Ratio Versus Lactate-albumin Ratio Among Critically Ill Patients in Sepsis and Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 28-Day All-Cause Mortality
研究概览
简要总结
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
This prospective observational cohort study compared the prognostic value of the neutrophil-to-lymphocyte ratio and the lactate-to-albumin ratio in adult patients with sepsis or septic shock admitted to the Surgical Intensive Care Unit at Benha University Hospital.
A total of 60 participants were enrolled and followed for 28 days. The study evaluated the relationship of both laboratory ratios with 28-day mortality and compared their ability to predict mortality. Intensive care unit length of stay and progression of organ dysfunction were also assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 to 60 years with clinically confirmed sepsis or septic shock.
- •Male and female patients.
- •Fulfillment of at least two quick Sequential Organ Failure Assessment criteria, including:
- •Glasgow Coma Scale score less than
- •Systolic blood pressure less than 100 millimeters of mercury.
- •Respiratory rate greater than 22 breaths per minute.
- •Evidence of infection-related organ dysfunction demonstrated by an increase of more than 2 points in the Sequential Organ Failure Assessment score.
- •Evidence of organ dysfunction, including one or more of the following:
- •Ratio of arterial partial pressure of oxygen to fraction of inspired oxygen less than
- •Glasgow Coma Scale score less than
- •Mean arterial pressure less than 70 millimeters of mercury.
- •Serum creatinine greater than 1.2 milligrams per deciliter.
- •Urine output less than 0.5 milliliters per kilogram per hour.
- •Serum bilirubin greater than 1.2 milligrams per deciliter.
- •Platelet count less than 150,000 per microliter.
- •For patients with septic shock, persistent hypotension requiring vasopressors to maintain mean arterial pressure above 65 millimeters of mercury and serum lactate greater than 2 millimoles per liter despite adequate fluid resuscitation.
- •Ability of the patient or legally authorized representative to provide informed consent.
排除标准
- •Active malignancy or chemotherapy within the previous 3 months.
- •Corticosteroid therapy within 90 days before admission.
- •Documented severe liver or kidney dysfunction.
- •Clinical conditions requiring albumin administration.
- •Pregnancy or breastfeeding.
- •Insufficient laboratory data or inability to complete follow-up.
研究组 & 干预措施
Sepsis and Septic Shock Cohort
Adult patients with sepsis or septic shock admitted to the Surgical Intensive Care Unit at Benha University Hospital. Participants underwent clinical and laboratory assessment, including measurement of the neutrophil-to-lymphocyte ratio and lactate-to-albumin ratio, and were followed for 28 days to assess mortality, intensive care unit length of stay, and progression of organ dysfunction.
结局指标
主要结局
28-Day All-Cause Mortality
时间窗: From intensive care unit admission through 28 days
The number and percentage of participants who died from any cause within 28 days after study enrollment.
次要结局
- Intensive Care Unit Length of Stay(From intensive care unit admission until intensive care unit discharge or death, assessed through 28 days)
- Change in Sequential Organ Failure Assessment Score(At intensive care unit admission, 6 hours, and 24 hours)
研究者
Abdallah Elhamy Labib El-Sayed
Dr
Benha University