The Relationship Between Popliteus and Quadriceps Muscle Thickness and Functional Capacity, Balance, and Pain in Elderly Patients With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 进行中(未招募)
- 发起方
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Knee Injury and Osteoarthritis Outcome Score (KOOS)
研究概览
简要总结
This study aims to examine the relationships between the ultrasonographic muscle thicknesses of the popliteus and quadriceps muscles and functional capacity, balance, and pain levels in elderly patients with knee osteoarthritis (KOA). Knee osteoarthritis is a major degenerative joint disorder causing pain, stiffness, and reduced mobility, where surrounding muscle architecture plays a pivotal role in functional performance and joint stability. The study will recruit approximately 150 participants aged 65 years and older with Grade 3-4 KOA (Kellgren-Lawrence) and intact cognitive status (SMMSE score ≥24) presenting to the Physical Medicine and Rehabilitation Outpatient Clinic of Afyonkarahisar Health Sciences University Health Application and Research Center, while excluding individuals with central nervous system, visual pathologies, or prior lower extremity surgeries. Muscle thicknesses of the popliteus and quadriceps (rectus femoris and vastus intermedius) will be measured via high-frequency B-mode ultrasonography by a specialist physician, using standardized anatomical landmarks and patient positioning. Functional capacity and mobility will be evaluated using the Timed Up and Go (TUG) and 5-Times Sit-to-Stand (5STS) tests, balance and proprioception via the Romberg Test, and knee-specific functional status and pain severity using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Visual Analog Scale (VAS).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 —(Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals aged 65 years and older
- •Individuals with a Standardized Mini-Mental State Examination (SMMSE) score of 24 and above
- •Individuals classified as Grade 3-4 according to the Kellgren-Lawrence grading scale
排除标准
- •Individuals under the age of 65
- •Individuals with an SMMSE score below 24
- •Individuals with central nervous system and visual pathologies that may affect balance
- •Individuals with a history of lower extremity surgery
研究组 & 干预措施
Knee OA Patients
Elderly patients diagnosed with knee osteoarthritis who meet the inclusion criteria. Popliteus and quadriceps muscle thickness will be measured using ultrasonography, and their relationship with functional capacity, balance, and pain levels will be evaluated.
结局指标
主要结局
Knee Injury and Osteoarthritis Outcome Score (KOOS)
时间窗: Baseline
KOOS is a comprehensive and reliable instrument for knee injuries and knee osteoarthritis. The scale consists of 5 subscales: Pain (9 items), Other Symptoms (7 items), Function in Daily Living (ADL) (17 items), Sport/Recreation Function (5 items), and Knee-Related Quality of Life (4 items). Each subscale is normalized to a score of 0-100, where 100 indicates no problems and 0 indicates extreme problems
Romberg Test
时间窗: Baseline
The patient is asked to stand upright with their feet together and arms hanging freely at their sides.The patient must wear hard, thin-soled shoes during this test. Without receiving any support, the patient is asked to stand first with eyes open and then with eyes closed. Safety precautions must be taken during this test to prevent falls; the examiner must remain close to the patient at all times and be prepared to catch them if they fall. In peripheral vestibular pathologies, the direction of sway/fall is toward the side of the lesion
Visual Analog Scale (VAS)
时间窗: Baseline
Participants will be asked to mark their average perceived pain intensity on a 10-centimeter (cm) line (defined as 0 = no pain, 10 = unbearable pain) during rest, activity, and sleep. Baseline pain scores will be obtained by measuring the distance between the marked point and the zero point using a ruler
Standardized Mini-Mental State Examination (SMMSE)
时间窗: Baseline
Developed by Folstein et al. in 1975 to assess cognitive status in adults. Its validity and reliability for the Turkish population were conducted by Güngen et al. A modified version is also available for individuals with less than five years of education. SMMSE is categorized under five main headings: orientation (10 points), registration/memory (3 points), attention and calculation (5 points), recall (3 points), and language (9 points). The scale is evaluated out of a total of 30 points. In scoring: results between 24 and 30 points indicate "normal" cognitive status, 18 to 23 points indicate "mild dementia," 12 to 17 points indicate "moderate dementia," and scores below 12 indicate "severe dementia" (Güngen et al., 2002). Individuals scoring 24 and above on the SMMSE were included in our study.
Ultrasound measurement of popliteus and quadriceps muscle thickness
时间窗: Baseline (single assessment visit)
Popliteus and quadriceps (rectus femoris + vastus intermedius) muscle thickness will be measured via B-mode ultrasonography using a high-frequency linear probe (10-15 MHz), with three measurements averaged per muscle. The correlation between mean popliteus and mean quadriceps thickness (mm) will be assessed using Pearson or Spearman correlation coefficients, depending on data distribution.
Timed Up and Go Test (TUG):
时间窗: baseline
The participant sits on a standard armless chair (43-46 cm height); upon the "start" command, they stand up, walk a marked 3-meter distance, turn, walk back to the chair, and sit down. The time elapsed from the start command until the participant sits down is recorded in seconds. The individual wears comfortable footwear, walks at a normal walking speed, and any standard assistive devices (e.g., cane) used are noted
5-Times Sit-to-Stand Test (5STS)
时间窗: Baseline
It is a reliable test used to assess sitting and standing ability. In older adults, it evaluates functional mobility, lower extremity muscle strength, and balance (19). The participant crosses their arms over their chest, and the time required to complete 5 consecutive sit-to-stand repetitions is measured.
次要结局
未报告次要终点
研究者
Gülşen Taşkın
asist. prof.
Afyonkarahisar Health Sciences University
