A Study to Determine the Safety and Efficacy of Atralin (Tretinoin 0.05%) Gel for the Treatment of Rosacea
- Registration Number
- NCT00621218
- Lead Sponsor
- Coria Laboratories, Ltd.
- Brief Summary
To compare the efficacy and safety of tretinoin gel 0.05% to its vehicle when dosed once or twice daily in female subjects with rosacea.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 36
Inclusion Criteria
- Female
- Age 18-65
- Diagnosed with classical, centrofacial, erythemato-telangiectatic rosacea
Exclusion Criteria
- Male, females less than 18 years
- Females over 65 years
- No diagnosed rosacea
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 tretinoin gel 0.05% - 2 vehicle -
- Primary Outcome Measures
Name Time Method Improvement in signs and symptoms of rosacea 16 weeks
- Secondary Outcome Measures
Name Time Method Changes in various skin parameters 16 weeks
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie tretinoin gel's efficacy in classical rosacea, particularly its interaction with retinoic acid receptors (RARs) and anti-inflammatory pathways?
How does tretinoin 0.05% gel compare to standard-of-care treatments like metronidazole or azelaic acid in managing erythematotelangiectatic rosacea symptoms?
Which inflammatory biomarkers (e.g., IL-1α, cathelicidin) predict response to tretinoin gel in female patients with classical rosacea?
What adverse events were observed in NCT00621218, and how do strategies like moisturizer use mitigate tretinoin-induced skin irritation in rosacea patients?
Are there synergistic effects when combining tretinoin gel with other retinoids (adapalene, tazarotene) or antibiotics in rosacea treatment?
Trial Locations
- Locations (1)
Product Investigations, Inc.
🇺🇸Conshohocken, Pennsylvania, United States
Product Investigations, Inc.🇺🇸Conshohocken, Pennsylvania, United States