Comparative assessment of total bacterial load in Orthodontic Patients undergoing fixed mechanotherapy subjected to different mouthrinses
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- total bacterial load
研究概览
简要总结
This interventional clinical study aimed to evaluate and compare the effectiveness of three different mouthrinses—probiotic, oil pulling, and chlorhexidine—in reducing the total bacterial load in orthodontic patients undergoing fixed mechanotherapy.
Using quantitative real-time PCR (qPCR) for precise microbial assessment, bacterial DNA was extracted from plaque samples collected before and after a 30-day intervention. The results showed that all three interventions significantly reduced bacterial counts, with chlorhexidine showing the greatest reduction, followed by oil pulling and probiotics.
The study highlights the potential of natural adjuncts like oil pulling and probiotics as effective and better-tolerated alternatives to chemical agents like chlorhexidine, especially for long-term oral microbial management during orthodontic treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 25.00 Year(s)（—）
- 性别
- All
入选标准
- •Subjects undergoing fixed orthodontic treatment with metal brackets and using conventional elastic ligatures.
- •Subjects falling under FAIR score in Debris index.
- •Subjects having full set of permanent dentition.
排除标准
- •Subjects with a history of antibiotic use in 3–4 weeks before the start of the study.
- •Subjects with any significant medical history during the last 1 month.
- •Subjects having very poor oral hygiene.
结局指标
主要结局
total bacterial load
时间窗: T1 (during orthodontic treatment) | T2 (after 2 months of use of mouthrinse)
次要结局
- Plaque scores(T1 (during orthodontic treatment))
研究者
Dr Ravindra Kumar Jain
Saveetha Dental College and Hospital, Chennai