Effects of adding celecoxib on brain-derived neurotrophic factor and on the severity of symptoms in patients with bipolar disorder who receive Electroconvulsive therapy
Not Applicable
- Conditions
- Bipolar Mood Disorder, Manic Episode.Manic episode
- Registration Number
- IRCT201401177202N7
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
meeting the DSM-IV criteria for manic episode of bipolar mood disorder; age between 17 and 65 years; order of receiving electroconvulsive therapy Exclusion criteria: history of allergy to NSAIDs; lactating and pregnant women, cerebrovascular hemorrhage; severe hepatic or renal disease, Patients with rheumatologic disease, organic brain syndrome, concomitant taking of other NSAIDs or corticosteroids, severe medical conditions like cardiovascular disorders, respiratory and gasterointestinal disease, receiving electroconvulsive therapy in the past 2 months, stroke, presence of contraindication of receiving electroconvulsive therapy
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in brain-derived neurotrophic factor. Timepoint: baseline and after sessions 1,3,6 of ECT. Method of measurement: measurment of serum level.
- Secondary Outcome Measures
Name Time Method Severity of mania. Timepoint: baseline and afterECT 3 and 6. Method of measurement: by Young Mania Rating Scale.