ebulized fentanyl compared to intravenous morphine for acute pain management in the Emergency Room: a randomized controlled trial, double blinded trial
Phase 3
Recruiting
- Conditions
- In Thailand, there are no pain protocol for acute pain management in emergency setting, pain killer are based on doctor considerationacute pain
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
1.ED patients age 18-65 years
2.Acute severe pain reported as : VAS > 7
Exclusion Criteria
1.Hemodynamic instability(SBP < 90 / > 180, HR < 50 / > 150, RR < 10 / > 30, BW <40 / > 115 kg
2.Abdominal pain
3.Asthma/COPD
4.Cirrhosis, CKD (Cr.CL. < 30)
5.Pain medication used within 4 h
6.Abused MAOIs within 2 wk
7.Opioid used more than 10 days
8.Pregnancy/lactation
9.Intracerebral hemorrhage
10.Patient positive for COVID-19/influenza/RSV/TB
11.History of fentanyl/morphine/ naloxone/ondansetron allergy
12.Inability to self-reported pain score; Altered mental status(GCS <15), Communication barrier
13.Plastic allergy / claustrophobia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain intensity reduction 15 min after received intervention Visual Analogue Scale (VAS)
- Secondary Outcome Measures
Name Time Method Pain intensity reduction 30, 45, 60 min post treatment Visual Analogue Scale (VAS),adverse events 15, 30, 45, 60 min post treatment record form,requirement for rescue therapy 15, 30, 45, 60 min post treatment record form