REM-sleep disruption and changes in noradrenergic neuronal reaction patterns in patients with sleep disorders or major depressio
Recruiting
- Conditions
- F33.2F51.0Recurrent depressive disorder, current episode severe without psychotic symptomsNonorganic insomnia
- Registration Number
- DRKS00016537
- Lead Sponsor
- Klinik für Psychiatrie und Psychotherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
•Ability to provide written informed consent
•Patients with MDD, eligible for and scheduled for treatment with VNS or Patients with ID or healthy controls
Exclusion Criteria
•Acute suicidal ideations
•Ongoing substance abuse
•For controls: current relevant psychiatric (for ID patients other than ID) or somatic disorder or recurring psychiatric disorder in the past
•Somatic medication potentially confounding outcome variable besides stable psychiatric medication in patients with MDD
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a)REML, REM (min), REM (%), REMD, EOGS, REM cycles<br>b)P3 amplitude, baseline pupil diameter<br>c)Change in BDI/HAMD/MADRAS baseline/12/18 months<br>
- Secondary Outcome Measures
Name Time Method a)NREM sleep parameters<br>b)Spectral EEG sleep parameters<br>c)Wake spectral EEG parameters<br>d)Stimulation intensities<br>e)Subjective assessments of sleep and depression<br>f)Comparison to healthy controls and patients with insomnia disorder<br>