Effect of Cetylated fatty acid topical cream on hand osteoarthritis: A randomized, double-blind study

Phase 2

• Conditions: onsteroidal antiinflammatory drugs (NSAID) reduce pain and improve function in hand OA.However nonselective NSAID carry dose-related gastrointestinal (GI) risks.Nonselective NSAID and cyclooxygenase-2 (COX-2)-selective inhibitors alike bear risks of cardiovascular and renal adverse effects.; Hand Osteoarthritis; OA hand; Cetylated fatty acid; CFA

• Registration Number: TCTR20210209008
• Lead Sponsor: Faculty of Medicine, Prince of Songkla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-09
• Study Completion: 2023-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 156

Inclusion Criteria

1. Diagnosed primary hand osteoarthritis by America college of rheumatology criteria
3. Visual analog scale 30-60 mm
4. 1, 2 and 3 Kellgren-Lawrence hand Osteoarthritis grading

Exclusion Criteria

1. History of hand surgery
2. History of hand intraarticular injection
3. Use oral corticosteroids in 3 months
4. Use supplementary drugs such as Glucosamine, Chondroitin and Diacerein in 3 months
5. History of other additional treatment such as hot pack, massage and splint
6. Secondary OA hand
7. Hand skin lesion
8. Pregnancy and lactation
9. NSAIDs and CFA allergy
10. On ASA, anti-platelet and anti-coagulant
11. Creatinine clearance < 30 ml/min

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Functional index for hand osteoarthritis(FIHOA) 6 weeks Questionnaire

Secondary Outcome Measures

Name	Time	Method
Visual analog score 6 weeks Millimeter,Patient global assessment 6 weeks Millimeter,Side effect such as Skin irritation 6 weeks Skin irritation criteria