Carotid Intima-media Thickness as Cardiovascular Mortality Predictor in Peritoneal Dialysis Patients

Completed

• Conditions: Myocardial Infarction

• Registration Number: NCT02938767
• Lead Sponsor: Istanbul University

Brief Summary

Cardiovascular (CV) disease is the main cause of death in patients on dialysis. The aim of this study is the long-term prognostic values of carotid intima-media thickness and coronary flow reserve in cardiovascular mortality of peritoneal dialysis patients.

Detailed Description

Endothelial dysfunction (ED) is a precursor and cause of cardiovascular diseases. Defining of endothelial thickness and coronary microvascular function could be useful for detecting ED. Endothelial dysfunction could be assessed by coronary flow reserve (CFR), carotid intima media thickness (IMT). Repeating measurement of IMT and CFR could be predictor of cardiovascular events and mortality in peritoneal dialysis patients.

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Status Verified: 2016-10
• Study First Submitted: 2016-10-17
• Study First Submitted QC: 2016-10-18
• Study First Posted: 2016-10-19
• Last Update Submitted: 2016-10-19
• Last Update Posted: 2016-10-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 57

Inclusion Criteria

• Peritoneal dialysis patients whose followed up at least six months from October 1994 to October 2011 (for study group)
• Kidney transplant recipients whose followed up at least six months from October 1994 to October 2011 (for control group)

Exclusion Criteria

• diabetes mellitus
• valvular heart disease,
• any prior coronary intervention and congestive heart failure
• Patients whose left anterior descending coronary artery (LAD) could not be visualized adequately by Doppler echocardiography were also excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diseases morbidity	10-15 years

Secondary Outcome Measures

Name	Time	Method
Patient Survival	10-15 years

Trial Locations

Locations (1)

Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine; 🇹🇷 Istanbul, Turkey