IRCT20210706051800N1招募中2 期
FLOT induction chemotherapy before neoadjuvant chemoradiotherapy and resectability and pathologic response in patients with esophagogastric junction and Proximal gastric adenocarcinomas
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 65 years（—）
- 性别
- All
入选标准
- •Appropriate performance status(ECOG score0-1)
- •Presence of pathologic diagnosis based on adenocarcinoma of the distal of esophagus and the proximal of stomach and the esophago-gastric junction
- •Resectable malignant lesion(stageIB-IIIB)
排除标准
- •Presence of siginificant comorbidity included uncontrolled diabetus mellitus,uncontrolled hypertension,history of ischemic heart disease and CABG,history of cerebrovascular accident(CVA),grade 2 or more neuropathy, failure of bone marrow(lymphopenia and leukopenia and thrombocytopenia in initial review),heart failure(EF=45%),renal dysfunction(GFR<50 mg/m),hepatic dysfunction (AST/ALT=3×ULN ? Billt=1.5×ULN) which prevents the prescription of neoadjuvant or surgery for the patient
- •History of collagen vascular disease
- •Presence of metastatic disease in initial review
- •History of previous chemotherapy or radiotherapy
- •History of malignancy of solid organs during the last 5 years( except skin BCC/SCC and cervical CIN which were treated with surgery
- •Advanced inoperable cancer
- •Pregnancy and breastfeeding
研究者
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