Conditioning Brain Responses for Modulating Corticospinal Excitability After ACL Reconstruction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Changes in corticospinal excitability
研究概览
简要总结
The purpose of this study is to examine if the changes in corticospinal function that accompany ACL reconstruction can be improved through a form of mental coaching and encouragement, known as operant conditioning.
详细描述
It is theorized reduced corticospinal excitability contributes to quadriceps dysfunction after knee injury and joint disease. Current rehabilitation does not directly target the alterations in corticospinal excitability, which may limit recovery. Operant conditioning is an emerging approach capable of increasing corticospinal excitability by directly targeting the corticospinal pathways. However, it remains to be determined whether operant conditioning of the corticospinal pathway may improve corticospinal function after knee trauma. Therefore, this study will evaluate the ability of operant up-conditioning of the corticospinal pathway to improve corticospinal function after ACL reconstruction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged 14-45 years
- •suffered an acute, complete ACL rupture
- •have undergone ACL reconstructive surgery
- •willingness to participate in testing and follow-up as outlined in the protocol
排除标准
- •have suffered a previous ACL injury on the contralateral leg
- •have undergone previous major surgery to the contralateral knee
- •have a history of recent significant knee injury (other than ACL) or lower-extremity fracture
- •have a history of uncontrolled diabetes or hypertension
- •be pregnant or plan to become pregnant
- •have metal implants in the head
- •have electronic devices in their ear or heart (e.g., cochlear implants or cardiac pacemakers)
- •have unexplained recurrent headaches
- •have a recent history of seizure
- •have a history of repeated fainting spells
结局指标
主要结局
Changes in corticospinal excitability
时间窗: Baseline (before the start of the intervention) and post-intervention (approximately 2 weeks after baseline)
Corticospinal excitability will be measured using transcranial magnetic stimulation at baseline and post-intervention and will be compared between groups.
次要结局
未报告次要终点
研究者
Riann Palmieri-Smith
Professor
University of Michigan