A case control study of trichoscopic evaluation of female pattern hair loss and its corelation with metabolic syndrome and fatty liver

Public title: Trichoscopic features of female pattern hair loss and their association with metabolic syndrome and fatty liver a hospital based case control study

Scientific title: A case control study of trichoscopic evaluation of female pattern hair loss and its correlation with metabolic syndrome and nonalcoholic fatty liver disease

Health condition studied: Female pattern hair loss metabolic syndrome fatty liver

Study design: Observational analytical hospital based case control with one to one matching cases are FPHL and controls are age matched women without alopecia

Study setting and site: Dermatology outpatient department teaching hospitals attached to Kasturba Medical College Mangalore Manipal Academy of Higher Education India

Participants: Females aged 18 years and above Cases: Clinical diagnosis of female pattern hair loss Controls: Age matched females without clinical hair loss

Inclusion criteria: Women 18 years or older willing to give consent for cases clinical female pattern hair loss for controls no alopecia or scalp disorder Exclusion criteria: Age below 18 years unwilling to participate conditions that may confound scalp assessment

Sample size: Total 112 with 56 cases and 56 controls

Study duration: 18 months anticipated first enrolment June 2025 and anticipated completion November 2026 Recruitment status: Not yet recruiting

Assessments and procedures: Clinical data demographics body mass index waist circumference blood pressure and grading of female pattern hair loss using Ludwig and Sinclair scales Trichoscopy at ten times polarized magnification over central frontal and parietal scalp recording hair shaft diameter diversity yellow dots peripilar signs and follicular unit changes Biochemistry fasting glucose lipid profile fasting insulin by ELISA with calculation of HOMA IR Ultrasound abdomen for fatty liver grading from 0 to 3 Definition of metabolic syndrome by NCEP ATP III at least three of five components

Primary outcomes: Prevalence of metabolic syndrome in cases versus controls and prevalence of fatty liver in cases versus controls

Secondary outcomes: Correlation of female pattern hair loss severity clinical and trichoscopic with metabolic parameters waist circumference blood pressure lipids glucose insulin HOMA IR and ultrasound fatty liver grade

Data analysis: Descriptive statistics chi square test for categorical variables t test or Mann Whitney U test for continuous variables significance level 0 point 05 software IBM SPSS version 29

Ethics: Institutional Ethics Committee approval will be obtained before enrolment written informed consent will be taken confidentiality will be maintained

Funding and sponsor: IADVL GRANT

Keywords: female pattern hair loss trichoscopy metabolic syndrome fatty liver HOMA IR case control India