Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease: an MRI-focused Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Change in anatomical structures by MRI
研究概览
简要总结
Barlow disease (BD) is a common cause of mitral insufficiency. In 2012 the University Hospital of Basel started to perform a simplified mitral valve repair technique in BD just by implanting an annuloplasty-ring. It is hypothesized that the major mechanism of the valvular insufficiency in Barlow disease is a deformation of the left ventricle and the posterior mitral annulus, causing its aberrant displacement during the systole towards posterior and basal and thus impairing the coaptation of the leaflets. This prospective individual MRI study is to investigate the ventricle and the mitral annulus pre- and postoperatively for detailed analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •identified Barlow disease suffering from significant mitral insufficiency with indication to surgery
排除标准
- •Active endocarditis or any other etiology of mitral insufficiency else than Barlow disease
- •Inability to perform a cardiac MRI (e.g., metallic implants, claustrophobia)
- •Pregnancy
- •Inability to give consent
结局指标
主要结局
Change in anatomical structures by MRI
时间窗: The first MRI will be performed on the admission day before surgery. The second MRI will be performed during the hospital stay, between 3 and 7 days after the operation.
Change in anatomical structures by MRI: distance (mm) between the mitral annulus and the cardiac apex during the cardiac cycle before and after surgical correction
次要结局
- function of the mitral valve by echocardiography(during the hospital stay, between 3 and 7 days after the operation and at cardiological follow-up over the first 3 months.)