Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis

• Conditions: Myasthenia Gravis
• Interventions: Other: reintubation

• Registration Number: NCT03597373
• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Brief Summary

Myasthenia gravis (MG) is an autoimmune disease that is characterized by muscle weakness and fatigue. The role of the thymus in MG has been suggested by the evidence that 10% to 15% of patients present with a thymoma and at least 60% with thymus hyperplasia or dysplasia.Beneficial effects of thymectomy in patients with MG have been described in 40% to 90%.Few studies have looked at the incidence of reintubation (not just within 24 hours after extubation), the factors associated with reintubation, and patient outcome.

Premature extubation may lead to hypercarbia, hypoxemia, pulmonary hypertension, right heart failure, and myocardial ischemia. Additionally, it subjects the patient to the physical risks of reintubation, including esophageal intubation, laryngeal trauma, and pulmonary aspiration. The purpose of the present study was to determine the incidence of reintubation, the variables associated with reintubation, and patient outcome

Detailed Description

Inclusion was based on the availability of all the following possible predictive pre-operative variables: age, gender, weight, height, body mass index, diabetes, creatinine, duration of MG, severity of MG (based on Osserman's classification), pathological type of MG, history of myasthenic crisis, dose of pyridostigmine, use of a steroid hormone, and use of an immunosuppressant.operative variables: postoperative pulmonary infection, total duration of hospital stay, duration of ICU stay, and duration of postoperative hospital stay. Variables were collected by research assistants and maintained in a computer database.

Study Timeline

• Study Start: 2017-01-01
• Status Verified: 2018-07
• Study First Submitted: 2018-07-13
• Study First Submitted QC: 2018-07-20
• Last Update Submitted: 2018-07-20
• Study First Posted: 2018-07-24
• Last Update Posted: 2018-07-24
• Primary Completion: 2019-01-01
• Study Completion: 2019-01-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• younger than 75 years
• absence of heart failure as the primary indication for mechanical ventilation •Acute Physiology and Chronic Health Evaluation (APACHE) II score less than 12 points on day of extubation
• body mass index less than 30

Exclusion Criteria

•preoperative moderate-to-severe chronic obstructive pulmonary disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
reintubation	reintubation	Reestablish of invasive mechanical ventilation
not reintubation	reintubation	Favourable respiratory function

Primary Outcome Measures

Name	Time	Method
Risk Factors for Reintubation	an average of 30 days	the reintubation rate was analyzed with logistic regression

Trial Locations

Locations (1)

Genglong Liu; 🇨🇳 Guangzhou, Guangdong, China