NCT03204006
Completed
Not Applicable
Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine
- Conditions
- Stress Response During Laryngoscopy Intubation
- Sponsor
- Assiut University
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- heart rate
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.
Investigators
Eman A. Ismail
Lecturer of anesthesia
Assiut University
Eligibility Criteria
Inclusion Criteria
- •- Age group 20-60 years
- •ASA grade 1 and 2
- •control hypertensive patients.
Exclusion Criteria
- •- Consent not given
- •ASA Grade 3 and 4
- •history of myocardial ischemia or infarction, or had an abnormal ECG on admission to the hospital
- •Patients with cardiovascular, pulmonary, hepatic, and renal disease.
- •Patients on B blockers.
- •patients with difficult airway; laryngoscopy and intubation time more than 20 s, or requiring more than two attempts will be exclude from the study.
Arms & Interventions
Dexmedetomidine group
35 patients will receive dexmedetomidine 0.5 µg/kg was administered intravenously using a syringe pump over 10 min sterile saline pre-induction of anesthesia.
Intervention: Dexmedetomidine
Control group
35 patients will receive sterile saline 0.5 µg/kg was administered intravenously using a syringe pump over 10 min pre-induction of anesthesia.
Intervention: sterile saline
Outcomes
Primary Outcomes
heart rate
Time Frame: through first 15 min post-induction of anesthesia
Secondary Outcomes
- systolic blood pressure(through first 15 min post-induction of anesthesia)
- diastolic blood pressure(through first 15 min post-induction of anesthesia)
Study Sites (1)
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