Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.

Not Applicable

Completed

• Conditions: Stress Response During Laryngoscopy Intubation
• Interventions: Drug: Dexmedetomidine; Drug: sterile saline

• Registration Number: NCT03204006
• Lead Sponsor: Assiut University

Brief Summary

Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-06-26
• Study First Submitted QC: 2017-06-28
• Study First Posted: 2017-06-29
• Study Start: 2018-03-08
• Status Verified: 2020-03
• Primary Completion: 2020-03-08
• Study Completion: 2020-03-12
• Last Update Submitted: 2020-04-05
• Last Update Posted: 2020-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• • Age group 20-60 years
• ASA grade 1 and 2
• control hypertensive patients.

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Exclusion Criteria

• • Consent not given
• ASA Grade 3 and 4
• history of myocardial ischemia or infarction, or had an abnormal ECG on admission to the hospital
• Patients with cardiovascular, pulmonary, hepatic, and renal disease.
• Patients on B blockers.
• patients with difficult airway; laryngoscopy and intubation time more than 20 s, or requiring more than two attempts will be exclude from the study.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexmedetomidine group	Dexmedetomidine	35 patients will receive dexmedetomidine 0.5 µg/kg was administered intravenously using a syringe pump over 10 min sterile saline pre-induction of anesthesia.
Control group	sterile saline	35 patients will receive sterile saline 0.5 µg/kg was administered intravenously using a syringe pump over 10 min pre-induction of anesthesia.

Primary Outcome Measures

Name	Time	Method
heart rate	through first 15 min post-induction of anesthesia

Secondary Outcome Measures

Name	Time	Method
systolic blood pressure	through first 15 min post-induction of anesthesia
diastolic blood pressure	through first 15 min post-induction of anesthesia

Trial Locations

Locations (1)

Assiut University Hospital; 🇪🇬 Assiut, Egypt