NCT03204006已完成不适用
Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- heart rate
研究概览
简要总结
Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age group 20-60 years
- •ASA grade 1 and 2
- •control hypertensive patients.
排除标准
- •- Consent not given
- •ASA Grade 3 and 4
- •history of myocardial ischemia or infarction, or had an abnormal ECG on admission to the hospital
- •Patients with cardiovascular, pulmonary, hepatic, and renal disease.
- •Patients on B blockers.
- •patients with difficult airway; laryngoscopy and intubation time more than 20 s, or requiring more than two attempts will be exclude from the study.
研究组 & 干预措施
Dexmedetomidine group
Active Comparator
35 patients will receive dexmedetomidine 0.5 µg/kg was administered intravenously using a syringe pump over 10 min sterile saline pre-induction of anesthesia.
干预措施: Dexmedetomidine (Drug)
Control group
Placebo Comparator
35 patients will receive sterile saline 0.5 µg/kg was administered intravenously using a syringe pump over 10 min pre-induction of anesthesia.
干预措施: sterile saline (Drug)
结局指标
主要结局
heart rate
时间窗: through first 15 min post-induction of anesthesia
次要结局
- systolic blood pressure(through first 15 min post-induction of anesthesia)
- diastolic blood pressure(through first 15 min post-induction of anesthesia)
研究者
Eman A. Ismail
Lecturer of anesthesia
Assiut University
研究点 (1)
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