Low-Level Laser Effects on Orthodontic Tooth Movement of Periodontally Compromised Patients.

Not Applicable

Active, not recruiting

• Conditions: Periodontal Diseases; Cancer Metastatic; Orthodontic Tooth Movement
• Interventions: Device: Biolase ;Low Level Laser

• Registration Number: NCT05739838
• Lead Sponsor: Faculty of Dental Medicine for Girls

Brief Summary

To investigate the effect of Low Level Laser therapy on orthodontic tooth movement of periodontally compromised patients by evaluating the rate of orthodontic tooth movement and the level of Osteocalcin in the gingival crevicular fluid.

Detailed Description

Low-Level laser therapy has been reported as an effective adjunct to non surgical periodontal treatment for inflammation control and tissue reparation in patients with periodontitis. Previous studies have shown that application of low-level laser therapy reduced pocket depth and decreased the inflammatory process through regulatory control of inflammatory cytokines level, therefore this study will investigate the effect of low-level laser on the periodontal tissue .Accelerating orthodontic tooth movement is one of the primary demand in orthodontics to prevent side effects as root resorption, caries and decreased patient compliance . Numerous researchers have also studied the use of LLLT in accelerating orthodontic tooth movement and have considered the laser to be effective while others achieved the opposite . Hence, This study is aiming to investigate the effects of LLLT in accelerating tooth movement.

Study Timeline

• Study Start: 2021-04-01
• Status Verified: 2023-02
• Study First Submitted: 2023-02-13
• Study First Submitted QC: 2023-02-13
• Study First Posted: 2023-02-22
• Last Update Submitted: 2023-02-23
• Last Update Posted: 2023-02-24
• Primary Completion: 2023-04
• Study Completion: 2023-05

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• No systemic disease.
• No history medication (antibiotics and/or anti inflammatory) in the previous 4 months.
• Self motivated patients with acceptable oral hygien.

Exclusion Criteria

• Previous orthodontic treatment
• Aggressive periodontitis
• Smokers
• pregnant patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Periodontally compromised patients subjected to low level laser therapy	Biolase ;Low Level Laser	periodontally compromised patients with pocket depth of more than 5 mm before receiving nonsurgical periodontal treatment treatment or/and pocket depth of less than 4 mm with periodontal status identified as stable for at least 3 month after nonsurgical periodontal treatment subjected to low-level laser of 940 nm will be applied at day one after start of treatment , weekly during the first month, then monthly.

Primary Outcome Measures

Name	Time	Method
Rate of orthodontic tooth movement	6 months	Rate of mandibular canine retraction

Secondary Outcome Measures

Name	Time	Method
Osteocalcin level in GCF	6 months	Gingival Crevicular Fluid samples will be collected from al target teeth in both groups to detect osteocalcin level after start of orthodontic treatment and at the end of the study

Trial Locations

Locations (1)

Faculty of dental medicine for Girls, AL Azhar University; 🇪🇬 Cairo, Egypt