eural reorganization in tinnitus: a high-field functional and antomical MRI study - Neural reorganization in tinnitus

niversiteit Maastricht0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•The main inclusion criteria of the patient groups are:
•* Male or female between 18 and 75 years
•* Subjective tinnitus (i.e. not caused by an acoustic source inside the head, e.g., vascular abnormalities that cause pulsatile tinnitus)
•* Stable tinnitus (i.e., present for at least 8 h per day since more than a year)
•* Tinnitus that is dominant within one of three octaves (low: <750 Hz, middle: 750-3000 Hz, high: >3000 Hz; the exact frequency ranges will be determined empirically based on patient availability)
•* Patient has not received medical care from an otolaryngologist and is able and willing to undergo the MRI measurements, as indicated by written informed consent.;The main inclusion criteria of the healthy subjects are:
•* Male or female between 18 and 75 years
•* No tinnitus
•* Subject is able and willing to undergo the MRI measurements, as indicated by written informed consent.

•Exclusion criteria of the patient groups are:
•* Fletcher Index > 50 dB HL for both ears (i.e., mean of hearing loss in decibels for 1k, 2k and 4k Hz)
•* Hyperacusis (oversensitivity to sound), phonophobia (defined as a persistent, abnormal, and unwarranted fear of sound), misophonia (dislike of certain sound),
•* Neurological-, neurosurgical- and psychiatric history
•* Use of dopaminergic drugs since this medication greatly influence the fMRI scans (Haslinger et al., 2001, Mattay et al., 2002)
•* Morbid obesitas (BMI > 35) since it cannot be guaranteed that these subjects will fit in the scanner
•* Current treatment of tinnitus and implanted devices or other metal objects that are not suitable for MRI. ;Exclusion criteria of the healthy subjects are:
•* Fletcher Index > 50 dB HL for both ears (i.e. mean of hearing loss in decibels for 1k, 2k and 4k Hz)
•* Hyperacusis (oversensitivity to sound), phonophobia (defined as a persistent, abnormal, and unwarranted fear of sound), misophonia (dislike of certain sound),
•* Neurological-, neurosurgical- and psychiatric history
•* Use of dopaminergic drugs since this medication greatly influence the fMRI scans (Haslinger et al., 2001, Mattay et al., 2002)
•* Morbid obesitas (BMI > 35) since it cannot be guaranteed that these subjects will fit in the scanner
•* Current treatment of tinnitus and implanted devices or other metal objects that are not suitable for MRI.

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