NL-OMON41097
Withdrawn
Not Applicable
eural reorganization in tinnitus: a high-field functional and antomical MRI study - Neural reorganization in tinnitus
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- phantom sound perception
- Sponsor
- niversiteit Maastricht
- Enrollment
- 30
- Status
- Withdrawn
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •The main inclusion criteria of the patient groups are:
- •\* Male or female between 18 and 75 years
- •\* Subjective tinnitus (i.e. not caused by an acoustic source inside the head, e.g., vascular abnormalities that cause pulsatile tinnitus)
- •\* Stable tinnitus (i.e., present for at least 8 h per day since more than a year)
- •\* Tinnitus that is dominant within one of three octaves (low: \<750 Hz, middle: 750\-3000 Hz, high: \>3000 Hz; the exact frequency ranges will be determined empirically based on patient availability)
- •\* Patient has not received medical care from an otolaryngologist and is able and willing to undergo the MRI measurements, as indicated by written informed consent.;The main inclusion criteria of the healthy subjects are:
- •\* Male or female between 18 and 75 years
- •\* No tinnitus
- •\* Subject is able and willing to undergo the MRI measurements, as indicated by written informed consent.
Exclusion Criteria
- •Exclusion criteria of the patient groups are:
- •\* Fletcher Index \> 50 dB HL for both ears (i.e., mean of hearing loss in decibels for 1k, 2k and 4k Hz)
- •\* Hyperacusis (oversensitivity to sound), phonophobia (defined as a persistent, abnormal, and unwarranted fear of sound), misophonia (dislike of certain sound),
- •\* Neurological\-, neurosurgical\- and psychiatric history
- •\* Use of dopaminergic drugs since this medication greatly influence the fMRI scans (Haslinger et al., 2001, Mattay et al., 2002\)
- •\* Morbid obesitas (BMI \> 35\) since it cannot be guaranteed that these subjects will fit in the scanner
- •\* Current treatment of tinnitus and implanted devices or other metal objects that are not suitable for MRI. ;Exclusion criteria of the healthy subjects are:
- •\* Fletcher Index \> 50 dB HL for both ears (i.e. mean of hearing loss in decibels for 1k, 2k and 4k Hz)
- •\* Hyperacusis (oversensitivity to sound), phonophobia (defined as a persistent, abnormal, and unwarranted fear of sound), misophonia (dislike of certain sound),
- •\* Neurological\-, neurosurgical\- and psychiatric history
Outcomes
Primary Outcomes
Not specified
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