The role of interleukin 17 and 10 (IL-17, IL-10) in adult female acne associated or not with risk factors for metabolic syndrome and modification after treatment: randomized and comparative clinical study - AFA Adult female acne

niversidade Federal de São Paulo0 个研究点开始时间: 2021年10月10日最近更新: 2023年5月29日

适应症

试验速览

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•Women aged between 25 and 44yo; presence of moderate facial acne (11 to 20 lesions); with or without scarring and sequels of hyperpigmentation; with no other signs or symptoms of hyperandrogenism; after informed consent and photographic consent signature.

•pregnant or lactating; light or severe acne; treatment of acne with oral cyclin group antibiotics (previous three months); oral isotretinoin (previous six months); topical products (previous three months, except cleansers, moisturizer and sunscreen); oral spironolactone at any time; combined oral contraceptive started in the last 6 months; other drugs: cortisone, lithium, anticonvulsants, isoniazid, androgens, danazol, iodides, bromides, disulphide, cyclosporine, azathioprine, thiourea, vitamins B2, B6 and B12; contraindications to the treatment options - for spironolactone: use of aldosterone antagonist (amiloride or eplerenone); renal insufficiency; hyperkalaemia; Addison’s disease; significant low blood pressure; hypersensivity to spironolactone; for AA: previous allergic or irritative symptoms to AA.

发起方

niversidade Federal de São Paulo