Using of Bone Marrow Derived Mesenchymal Stem Cells For Treatment of Azoospermic Patients
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- All Cases Improvement
研究概览
简要总结
In this study, we performed autologous BMDMSC transplantation to the testis of Azoospermic patients in a trial to enhance and activate the spermatogonial stem cells of the testis and aiming to produce motile sperm.
详细描述
Bone marrow aspirated and stem cells were isolated, cultured and characterized using flow cytometer. Stem cells prepared according to GMP regulations then injected into rete testis using special syringe. Patients follow up will carried out for a year , three month interval. FSH, testosterone, testicular size as well as sexual potency will assessed every three months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •All Non obstructive Azoospermic Patients.
- •Azoospermic Patients due to Administration of Chemo/Radiotherapy.
排除标准
- •Patients with Testicular Cancer.
- •Patients with Complete Deletion of Chromosome Y AZF (a,b,c) Regions.
结局指标
主要结局
All Cases Improvement
时间窗: One Year (12-Month)
Hormonal Assessment: Serum (Testosterone , FSH, LH and Prolactin). Testicular Size. Sexual Potency.
次要结局
- All Cases Fertility Improvement(One Year (12-Month))
研究者
Sayed Bakry
Associate Professor , Consultant of Separation and Culturing of Stem Cells
Al-Azhar University