Evaluation of small-airway dysfunction in chronic obstructive pulmonary disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- prevalence of small airway dysfunction in COPD groups
研究概览
简要总结
This is a cross-sectional study to observe the prevalence of small airway dysfunction in different COPD groups. These groups are per the Global initiative for chronic obstructive lung disease (GOLD) guideline. The COPD groups are classified based on the severity of symptoms and history of exacerbation in the past 1 year. This study will help to calculate the burden of small airway dysfunction in different COPD groups in patients from India. It will also help how the current recommended treatment by GOLD changes the small airway dysfunction measured in terms of forced oscillation technique, spirometry, and Body plethysmography and whether this small airway dysfunction is related to the quality of life measured in terms of COPD ASSESSMENT TEST(CAT) scoring.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •Diagnosed cases of COPD as per 2021 GOLD (Global initiatives for Obstructive Lung Disease) guidelines (Post BDR FEV1/FVC < 0.7 and β2 agonists reversibility of less than 12% or 200ml)(36).
排除标准
- •â€“Not able to perform an acceptable test –Hemodynamically compromised –Exacerbation of COPD within past 4 weeks –Other lung diseases like TB, asthma, interstitial lung diseases, structural lung diseases, e.g., bronchiectasis, lung cancer, respiratory infection in 2 weeks, history of pulmonary surgery –Pregnant women.
结局指标
主要结局
prevalence of small airway dysfunction in COPD groups
时间窗: at the point of interaction
次要结局
- monitoring lung function parameters after optimised treatment(3 months and 1 year)
- quality of life as CAT score(with oscillatory technique parameters, like R5, X5, EFL, R5-19)