Impact of dementia-related neurodegeneration on pain processing

Completed

• Conditions: Alzheimer desease; dementia; 10007963; 10012272

• Registration Number: NL-OMON47032
• Lead Sponsor: Huisartsgeneeskunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 125

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:;All subjects:
- Age from 55 * 85 yr
- Willingness to cooperate and sign written informed consent * or proxy consent with assent of participating subject;Normal Healthy Controls (CP):
- MMSE scores between 27-30
- Without subjective memory complaints;Alzheimers*s disease dementia (AD):
- Diagnosis of probable AD according to the Alzheimer*s disease and Related Disorders Associations (NINCDS-ADRDA) criteria and NIA-AA guidelines ( McKhann et al. 2011).;Frontotemporal dementia (FTD):
- Diagnosis of behavioral variant FTD (FTD-b) according to the revised consensus criteria (Rascovsky et al. 2011).
- Diagnosis of a subtype of FTD of Primary Progressive Aphasia (PPA), divided into Semantic Dementia (SD), Progressive Nonfluent Aphasia (PNFA) and LPA due to FTD (Gorno-Tempini et al. 2011). ;Vascular dementia (VD):
- Diagnosis of probable VD according to the NINDS-AIREN (National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l*Enseignement en Neurosciences) guidelines (Roman et al. 1993).

Exclusion Criteria

All subjects:
- History of major psychiatric illness
- Medications which may affect pain processing (selective serotonin re-uptake inhibitors, opioids, other analgesics)
- Contraindications for MR-measurements (e.g. cochlear implants and most permanent pacemakers, red tattoos);Normal healthy Controls:
- abnormal results on neuropsychological tests
- subjective memory complaints;All patients:
- Cognitive deficits could be explained by non-neurodegenerative condition (e.g. stroke, neoplasm, head injury, hydrocephalus or other medical condition)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Response to various mild pain stimuli (pressure pain will be applied to the<br /><br>shoulder and temperature (heat) will be applied to the forearm )<br /><br>- Self -report<br /><br>- Facial expression (the face will be videotaped and analyzed using the Facial<br /><br>Action Coding System)<br /><br>- Heartrate and heartrate-variability</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- structural MRI (grey and white matter (especially in frontal areas))<br /><br>- Neuropsychology testing (attention, memory, executive functioning)</p><br>