Effect of deep Transcranial Magnetic Stimulation in patients with OCD and it’s study using Functional Magnetic Resonance Imaging scan

Phase 3

Not yet recruiting

• Conditions: Mixed obsessional thoughts and acts, (2) ICD-10 Condition: F429||Obsessive-compulsive disorder, unspecified, (3) ICD-10 Condition: F428||Other obsessive-compulsive disorder,

• Registration Number: CTRI/2020/07/026407
• Lead Sponsor: Central Institute of Psychiatry

Brief Summary

OCD is a chronic debilitating condition which often responds incompletely to available psychopharmacology and psychotherapy. Deep Transcranial Magnetic Stimulation has a deeper penetration than classical TMSand can stimulate deeper brain structures. Using H7 coil, anterior cingulate cortex and medial prefrontal cortex will be stimulated and it’s effect will be assessed using clinical rating scales and fMRI.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-02-07
• Study Start: 2020-11-07

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Diagnosis of Obsessive-Compulsive Disorder using Diagnostic Criteria for Research (DCR) of ICD 10 DCR (WHO, 1993) 2.
• Y-BOCS score of 15 or above 3.
• Age between 18-60 years of either sex 4.
• Right-handed 5.
• Educational qualification of class VIII and above 6.
• Patients giving written informed consent.

Exclusion Criteria

• Co-morbid severe depression as measured by a HAM-D score of 23 or more 2.
• Patients with co-morbid neurological or any other psychiatric disorder 3.
• Patients who cannot undergo MRI scan 4.
• Colour blind, as indicated by Ishihara’s charts.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome of the study is the clinical improvement in patients with OCD as recorded on Y-BOCS scale as seen at the end of 2 weeks of high frequency dTMS treatment.	1. At baseline | 2. Day 1 (after 1st session of dTMS/sham stimulation ) | 3. Day 14 (at the end of 10 sessions of stimulation)

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes are the changes in functional activation of ACC and mPFC as measured by resting state fMRI and Stroop task evoked fMRI following 10 session of high frequency dTMS in patients with OCD.	1. At baseline

Trial Locations

Locations (1)

Central Institute of Psychiatry, Kanke, Anchi; 🇮🇳 Ranchi, JHARKHAND, India

Central Institute of Psychiatry, Kanke, Anchi

🇮🇳Ranchi, JHARKHAND, India

Sachin Reddy KR

Principal investigator

9986273710

snsachinnandu@gmail.com