CTRI/2024/03/064152尚未招募Unknown
PRECEDE: The Pancreatic Cancer Early Detection Consortium - Precede
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Individuals from the following groups who present for clinical evaluation and assessment of PDAC risk at Max Super speciality hospital can be offered participation in the PRECEDE database:
- •Individuals without history of PDAC meeting any of the following criteria:
- •1. 2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject; age 50+ or =10 years younger than earliest PDAC in family at time of diagnosis.
- •2. 2 affected first degree relatives with PDAC; age 50+ or 10 years younger than earliest PDAC in family
- •3. BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, MSH6, PMS2, EPCAM pathogenic or likely pathogenic variant AND 1 first or second degree relative with PDAC; age 50+ or 10 years younger than earliest PDAC in family
- •4. Familial Atypical Moles and Malignant Melanoma (FAMMM) with pathogenic or likely pathogenic CDKN2A variant; age 40+
- •5. Peutz-Jegher syndrome with STK11 pathogenic or likely pathogenic variant; age 35+
- •6. Hereditary pancreatitis with PRSS1 pathogenic or likely pathogenic variant and history of pancreatitis; age 40+
- •Individuals without history of PDAC meeting any of the following criteria:
- •1. ATM, BRCA1, BRCA2, or PALB2 pathogenic or likely pathogenic variant regardless of family history, age 50+
- •2. 2+ relatives with PDAC on the same side of family, any degree of relation, not meeting other criteria above; age 50+ or 10 years younger than earliest PDAC in family
- •3. 1 first degree relative with PDAC = age 45; age up to 10 years younger than PDAC diagnosis in family member
- •Individual meeting criteria for Cohorts 1 or 2 EXCEPT age (i.e. too young to qualify for Cohorts 1 or 2)
- •Individuals without history of PDAC presenting for evaluation who do not meet any criteria for 1-3, 6, or the Cyst Cohort.
- •Individuals who are not otherwise engaged in pancreas surveillance at a participating site may be invited to participate in the PRECEDE database and to donate a biosample (e.g. blood, saliva, and/or buccal swab) for discovery studies. This may include relatives of individuals in Cohorts 1-4, 6, and the Cyst Cohort.
- •Individuals with a personal history of PDAC meeting any of the following criteria:
- •1. Family history includes at least one first degree relative with PDAC, or 2 relatives with PDAC who are first degree related to each other
- •2. Personal or family history of a pathogenic or likely pathogenic germline variant in ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2,PMS2, PRSS1, STK11
- •3. Diagnosed = age 45
- •Cyst Cohort
- •Individuals with a personal history of a pancreatic cystic neoplasm not meeting any criteria for Cohorts 1-3 or 6 (no known family history of PDAC, no known pathogenic germline variants linked to PDAC risk)
排除标准
- 未提供
研究者
相似试验
招募中
不适用
Project for Detection of Early Pancreatic Cancer in Gifu Multi-center prospective cohort studypancreatic cancerJPRN-UMIN000028714First Department of Internal Medicine, Gifu University Hospital500
进行中（未招募）
不适用
K early detection initiative for pancreatic cancerPancreatic cancerCancerISRCTN12805385niversity of Liverpool2,500
招募中
不适用
Early detection of pancreatic cancer with endoscopic ultrasoundPancreatic cancerJPRN-UMIN000030474Wakayama Medical University2,500
尚未招募
Unknown
YCU Early Detection Project of Pancreatic cancer led by EUS 2023- Prospective observational studyPancreatic cancerJPRN-UMIN000049449Endoscopic Unit, Yokohama City University Hospital5,000
招募中
不适用
Development of diagnosis of early pancreatic cancer patients in JapaPancreatic CancerJPRN-UMIN000019371Department of Surgery, Osaka University Graduate School of Medicine650