NCT03347318进行中（未招募）不适用
Non-interventional Study for the Determination of Molecular Resistance Profiling to Targeted Therapies in Patients With Neoplastic Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 2,500
- 试验地点
- 15
- 主要终点
- number of patient correctly sampled
研究概览
简要总结
The main purpose of this study is to define the molecular profile of selected solid tumors. From each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. Whereas possible, vital tumor specimens will be inoculated and propagated in immunocompromised NOD/SCID mice to study the genetic correlations between genetic status and response to target drugs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with at least one of the following selected solid tumors:
- •Colorectal Cancer (primary or with synchronous/metachronous liver metastases)
- •Prostate Cancer
- •Head & Neck Tumors
- •Gastric Cancer
- •Glioblastoma
- •Breast Cancer
- •Hepatocarcinoma
- •Biliary Tract Carcinoma
- •Lung Cancer (primary)
- •Rare Tumors (incidence ≤ 5x10-6)
- •Metastatic Sarcoma
- •Metastatic Melanoma
排除标准
- 未提供
结局指标
主要结局
number of patient correctly sampled
时间窗: through study completion, an average of five years
number of patients with biological samples idoneous for molecular profiling testing (nucleic acid extraction, protein) over all recruited patients.
次要结局
- number of patients with detected genetic alterations that respond to treatments assigned by physician.(through study completion, an average of five years)
研究者
研究点 (15)
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