prospective randomized comparison of an automatically defined scan delay and a manually defined scan delay in coronary CT angiography

Not Applicable

• Conditions: coronary heart diseasecoronary anomaly; I20-I25; Ischaemic heart diseases

• Registration Number: DRKS00012750
• Lead Sponsor: Klinikum der Universität München, Campus Großhadern

Brief Summary

Results: With the current bolus tracking technique, interpatient variations decrease with higher IDRs and earlier triggering (lower tube voltage and/or lower trigger value), and the true PTDs increase linearly with injection duration. Compared with the current bolus tracking method, the systematic and random errors of the algorithm-predicted PTDs are smaller, do not depend on the IDR, and are predictable over a large range of total iodine doses. The median difference between the true and algorithm-predicted PTD is less than ±1 second for all IDRs and injection durations, and the algorithm was able to predict patient-specific PTDs within ±2 seconds from the true PTD in more than 90% of patients for almost all injection protocols. Conclusions: The new algorithm can robustly predict a patient-specific time of arterial peak enhancement and is better than a best-case scenario for the current bolus tracking technique because interpatient variations are taken into account. It offers a new framework for scan timing optimization and can potentially be used for personalized scan timing in real time.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-14
• Study Completion: 2018-07-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Coronary CT angiography performed within clinical routine
• Stable heart rate below 65 beats per minute to be tested with low-dose technique

Exclusion Criteria

• arrhythmia
• Heart rate = 65 beats per minute
• Allergy to iodinated contrast agent
• renal failure
• hyperthyroidism

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint is the achieved CT density in the left ventricle as well as in the aortic bulbus. The CT density is systematically analyzed in all patients after completion of the recruitment. Therefore, in the CT data the average CT density is determined in a 1 cm² measurement in the left ventricular cavity as well as in the aortic bulbus.

Secondary Outcome Measures

Name	Time	Method
Overall image quality of the coronary arteries using a semi-quantitative Image quality score (Grade 1-4)