Effects of Mirror Therapy Combined With Contralaterally Controlled Functional Electrical Stimulation on Functional Recovery and Neuroplasticity in Patients With Peripheral Nerve Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- change from baseline in corticomuscular coherence at week 12
研究概览
简要总结
The goal of this trial is to evaluate the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on motor recovery and neuroplasticity in patients with peripheral nerve injury. The main questions it aims to answer are Question 1: To compare corticomuscular coherence between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group.
Question 2: To compare sensorimotor recovery between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group.
Question 3: To evaluate the effects of each intervention on corticomuscular coherence and sensorimotor recovery 12 weeks post-intervention.
Participants will be asked to exercise their affected hand together with the unaffected hand while receiving contralaterally controlled electrical stimulation in front of the mirror or sham mirror. Researchers will compare the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on corticomuscular coherence and sensorimotor recovery with the other groups.
详细描述
The goal of this trial is to evaluate the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on motor recovery and neuroplasticity in patients with peripheral nerve injury. The main questions it aims to answer are:
Question 1: To compare corticomuscular coherence between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group.
Question 2: To compare sensorimotor recovery between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group.
Question 3: To evaluate the effects of each intervention on corticomuscular coherence and sensorimotor recovery 12 weeks post-intervention.
Eligible participants will be randomized into three groups:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •newly diagnosed median or ulnar nerve transection injury of the forearm in the past 6 months
- •sufficient communication in the Chinese language
- •being able to follow instructions
- •the presence of target muscle denervation (e.g. muscle atrophy, inability to actively contract)
- •less than 10% surface EMG activity during pinch evaluation compared to the unaffected side
排除标准
- •had central nervous disease
- •had a recent (1 year) history of nerve entrapment syndrome
- •had a history of latent neuropathy, such as diabetes or dialysis
研究组 & 干预措施
MT and CCFES group
mirror therapy combined with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: mirror therapy (Behavioral)
MT and CCFES group
mirror therapy combined with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: contralaterally controlled functional electrical stimulation (Device)
MT and CCFES group
mirror therapy combined with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: conventional physiotherapy (Behavioral)
Sham MT and CCFES group
sham mirror therapy with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: contralaterally controlled functional electrical stimulation (Device)
Sham MT and CCFES group
sham mirror therapy with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: conventional physiotherapy (Behavioral)
Control group
conventional physiotherapy
干预措施: conventional physiotherapy (Behavioral)
结局指标
主要结局
change from baseline in corticomuscular coherence at week 12
时间窗: baseline, week 12
coherence will be used to analyze the interaction between the electroencephalogram activation and electromyography activation
次要结局
- change from baseline in pinch strength at week 12(baseline, week 12)
- change from baseline in maximum voluntary isometric contraction in surface EMG at week 12(baseline, week 12)
- change from baseline in grip strength at week 12(baseline, week 12)
- change from baseline in sensation on Semmes-Weinstein monofilament test at week 12(baseline, week 12)
- change from baseline in function on Disabilities of the Arm, Shoulder, and Hand outcome questionnaire at week 12(baseline, week 12)