Effects of Mirror Therapy Combined With Contralaterally Controlled Functional Electrical Stimulation on Functional Recovery and Neuroplasticity in Patients With Peripheral Nerve Injury
概览
- 阶段
- 不适用
- 干预措施
- mirror therapy
- 疾病 / 适应症
- Peripheral Nerve Injury
- 发起方
- National Taiwan University Hospital
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- change from baseline in corticomuscular coherence at week 12
- 状态
- 已完成
- 最后更新
- 3个月前
概览
简要总结
The goal of this trial is to evaluate the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on motor recovery and neuroplasticity in patients with peripheral nerve injury. The main questions it aims to answer are Question 1: To compare corticomuscular coherence between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group.
Question 2: To compare sensorimotor recovery between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group.
Question 3: To evaluate the effects of each intervention on corticomuscular coherence and sensorimotor recovery 12 weeks post-intervention.
Participants will be asked to exercise their affected hand together with the unaffected hand while receiving contralaterally controlled electrical stimulation in front of the mirror or sham mirror. Researchers will compare the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on corticomuscular coherence and sensorimotor recovery with the other groups.
详细描述
The goal of this trial is to evaluate the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on motor recovery and neuroplasticity in patients with peripheral nerve injury. The main questions it aims to answer are: Question 1: To compare corticomuscular coherence between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group. Question 2: To compare sensorimotor recovery between the groups of mirror therapy combined with contralaterally controlled functional electrical stimulation, sham mirror therapy combined with contralaterally controlled functional electrical stimulation, and control group. Question 3: To evaluate the effects of each intervention on corticomuscular coherence and sensorimotor recovery 12 weeks post-intervention. Eligible participants will be randomized into three groups: MT and CCFES group: mirror therapy combined with contralaterally controlled functional electrical stimulation Sham MT and CCFES group: Sham mirror therapy combined with contralaterally controlled functional electrical stimulation Control group: conventional physiotherapy. Each participant will receive conventional physiotherapy for 50 minutes daily, twice a week for 12 weeks. Conventional physiotherapy includes scar management, joint range of motion exercise, strengthening, stretching, and functional training. Participants in the MT and CCFES group or Sham MT and CCFES group will receive 30 minutes daily, twice a week of the intervention for 12 weeks in addition to the conventional physiotherapy. In the MT and CCFES group, the participants will sit in front of the mirror and watch the mirror reflection of the unaffected hands. At the same time, contralaterally controlled electrical stimulation will be conducted to make the affected hands move with the unaffected hands. The participants in the Sham MT and CCFES group will sit in front of the mirror without mirror reflection, but doing the exercise with contralaterally controlled functional electrical stimulation. All participants will receive the evaluations at baseline and 12 weeks after the intervention. The evaluations include: Electroencephalography of α and β bands from the sensorimotor cortices will be recorded. Electromyography will be performed during maximum isometric pinch or lateral pinch strength measurements. Maximum isometric grip strength, tip pinch strength, lateral pinch strength, sensation tests, and upper extremity function will be measured.
研究者
入排标准
入选标准
- •newly diagnosed median or ulnar nerve transection injury of the forearm in the past 6 months
- •sufficient communication in the Chinese language
- •being able to follow instructions
- •the presence of target muscle denervation (e.g. muscle atrophy, inability to actively contract)
- •less than 10% surface EMG activity during pinch evaluation compared to the unaffected side
排除标准
- •had central nervous disease
- •had a recent (1 year) history of nerve entrapment syndrome
- •had a history of latent neuropathy, such as diabetes or dialysis
研究组 & 干预措施
MT and CCFES group
mirror therapy combined with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: mirror therapy
MT and CCFES group
mirror therapy combined with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: contralaterally controlled functional electrical stimulation
MT and CCFES group
mirror therapy combined with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: conventional physiotherapy
Sham MT and CCFES group
sham mirror therapy with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: contralaterally controlled functional electrical stimulation
Sham MT and CCFES group
sham mirror therapy with contralaterally controlled functional electrical stimulation to perform hand exercises
干预措施: conventional physiotherapy
Control group
conventional physiotherapy
干预措施: conventional physiotherapy
结局指标
主要结局
change from baseline in corticomuscular coherence at week 12
时间窗: baseline, week 12
coherence will be used to analyze the interaction between the electroencephalogram activation and electromyography activation
次要结局
- change from baseline in pinch strength at week 12(baseline, week 12)
- change from baseline in maximum voluntary isometric contraction in surface EMG at week 12(baseline, week 12)
- change from baseline in grip strength at week 12(baseline, week 12)
- change from baseline in sensation on Semmes-Weinstein monofilament test at week 12(baseline, week 12)
- change from baseline in function on Disabilities of the Arm, Shoulder, and Hand outcome questionnaire at week 12(baseline, week 12)