ow dose chemoprophylaxis (LDCP) and reduction of pyelonephritic episodes and significant bacteriuria in children with meningomyelocele and clean intermittent catheterisation (CIC)
Not Applicable
Completed
- Conditions
- Meningomyelocele (MMC)Not ApplicableSpina bifida
- Registration Number
- ISRCTN56278131
- Lead Sponsor
- niversity Medical Centre Utrecht (UMCU) (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 170
Inclusion Criteria
1. Neuropathic bladder-sphincter dysfunction
2. CIC and use of LDCP for at least 6 months
3. Good possibilities for communication
4. Written informed consent
Exclusion Criteria
1. Urinary tract infection (UTI) or - pyelonephritis at inclusion
2. Fever of unknown origin (e causa ignota [ECI])
3. Other neurologic diseases
4. Other diseases like IDDM that can cause UTI
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Number of urinary tract infections<br>2. Number of pyelonephritic episodes
- Secondary Outcome Measures
Name Time Method Changes in antibiotic resistance patterns in the cultured uropathogens