Determinants of insulin-induced weight gain in patients with type 2 diabetes mellitus, a study on liver fat content, physical activity and metabolic markers comparing weight gainers vs. non-weight gainers
- Conditions
- type 2 diabetes mellitus10012653
- Registration Number
- NL-OMON31007
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
· Type 2 diabetes mellitus
· Premixed insulin
· Age 20-85 years
· HbA1c < 8.5%
· Increase in body weight defined as a weight increase > 6 kg in any given period of 12 months (> 0.5 kg/months over 12 months) over a time period of 12-36 months after start of insulin therapy
· Stable body weight
· Current insulin dose >0.4 IU/kg - < 1.2 IU/kg
· Written informed consent
· Clinical evidence of cardiovascular or liver or other disease
· Treatment with drugs that may alter glucose tolerance, abnormal serum creatinine, macroalbuminuria, proliferative retinopathy, excessive alcohol consumption (>20 g/day), and drug abuse
· Use of thiazolidinedione derivatives (TZDs)
· Patients with pacemakers, ICD*s, implants of metal (prosthesis, (cochlear) ear implants) and patients who experience claustrophobia
· Pregnancy or intention to become pregnant during the study
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method