Determinants of insulin-induced weight gain in patients with type 2 diabetes mellitus, a study on liver fat content, physical activity and metabolic markers comparing weight gainers vs. non-weight gainers - Weight gain and insulin therapy

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年5月13日

试验速览

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•· Type 2 diabetes mellitus
•· Premixed insulin
•· Age 20-85 years
•· HbA1c < 8.5%
•· Increase in body weight defined as a weight increase > 6 kg in any given period of 12 months (> 0.5 kg/months over 12 months) over a time period of 12-36 months after start of insulin therapy
•· Stable body weight
•· Current insulin dose >0.4 IU/kg - < 1.2 IU/kg
•· Written informed consent

•· Clinical evidence of cardiovascular or liver or other disease
•· Treatment with drugs that may alter glucose tolerance, abnormal serum creatinine, macroalbuminuria, proliferative retinopathy, excessive alcohol consumption (>20 g/day), and drug abuse
•· Use of thiazolidinedione derivatives (TZDs)
•· Patients with pacemakers, ICD*s, implants of metal (prosthesis, (cochlear) ear implants) and patients who experience claustrophobia
•· Pregnancy or intention to become pregnant during the study

发起方

niversitair Medisch Centrum Sint Radboud