COST-UTILITY ANALYSIS OF ANTIBIOTICS COMPARED WITH OPERATIVE TREATMENT IN UNCOMPLICATED ACUTE APPENDICITIS

Completed

• Conditions: Most economic evidence has been generated from developed countries, with evidence from developing countries lacking, particularly using CUA from a societal perspective. As such, this study used real practice data to assess clinical effectiveness and CUA comparing individual antibiotics with appendectomy. This evidence will inform general surgeons in treatment management for uncomplicated acute appendicitis.; Cost-utility; appendicitis; antibiotics; appendectomy

• Registration Number: TCTR20210623005
• Lead Sponsor: Department of Clinical Epidemiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University

Brief Summary

Antibiotic treatments represent a lower cost treatment option with better cost utility compared to operative treatment options in uncomplicated acute appendicitis patients. As such, antibiotic treatment should be considered as an alternative option to minimize complication rates associated with operative treatments.

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-05-29
• Study Start: 2021-06-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 226

Inclusion Criteria

Adult patients who were diagnosed with uncomplicated appendicitis (proven by ultrasonography or computer tomography)

Exclusion Criteria

Patients later diagnosed as complicated appendicitis were excluded

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cost 1 time at discharge date direct medical cost, direct non-medical and indirect costs

Secondary Outcome Measures

Name	Time	Method
tility 1. Before receiving treatment, 2. At discharge day, 3. At one week, 4. At one month European Quality of Life-5 Dimensions (EQ5D-5L)