Relationship Between Acute Phase Markers and Post-operative Pain in Open Tension-free Inguinal Hernia Repair: An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 71
- 试验地点
- 1
- 主要终点
- Relationship Between Post-operative Pain and C Reactive Protein (CRP) in Open Tension-free Inguinal Hernia Repair
研究概览
简要总结
Many patients undergoing inguinal hernia repair are prone to developing acute and chronic post-operative pain.
The aim of the study is to show a possible correlation between pain and acute phase proteins in order to:
- predict the severity of pain;
- select most suitable pain relief therapy for the patient.
详细描述
The day after surgery, some serum markers are determined by a blood sample.
The markers analyzed are:
- Leukocytes;
- C-reactive protein (CRP);
- D-dimer;
- Fibrinogen;
- Neutrophil-to-Lymphocyte Ratio (NLR).
Pain level is assessed using the NRS scale at different times:
- 1st post-operative day;
- 7th post-operative day;
- One month after surgery;
- Three months after surgery;
- Six months after surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient undergoing Open Tension-free Inguinal Hernia Repair
排除标准
- 未提供
结局指标
主要结局
Relationship Between Post-operative Pain and C Reactive Protein (CRP) in Open Tension-free Inguinal Hernia Repair
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with CRP (μg/L) levels 24 hours after surgery
Relationship Between Post-operative Pain and Neutrophil to Lymphocyte Ratio (NLR) in Open Tension-free Inguinal Hernia Repair
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with Neutrophil to Lymphocyte Ratio (NLR) 24 hours after surgery
Relationship Between Post-operative Pain and D-dimer in Open Tension-free Inguinal Hernia Repair
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with D-dimer (μg/L FEU) levels 24 hours after surgery
Relationship Between Post-operative Pain and Fibrinogen in Open Tension-free Inguinal Hernia Repair
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with fibrinogen (g/L) levels 24 hours after surgery
Relationship Between Post-operative Pain and white blood cell count in Open Tension-free Inguinal Hernia Repair
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with white blood cell count (x 10\^9/L) 24 hours after surgery
次要结局
未报告次要终点
研究者
Augusto Lauro
Associate professor
University of Roma La Sapienza