Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis

Completed

• Conditions: Optic Neuritis

• Registration Number: NCT03963310
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

The visual prognosis of optic neuritis not related to multiple sclerosis is unknown, both in terms of functional recovery and evolution.

This prospective cohort study aim to assess the ophthalmological evolution of patients presenting an episode of optic neuritis (NO) not related to a multiple sclerosis or to a clinically isolated syndrome.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-05-20
• Study First Submitted QC: 2019-05-22
• Study First Posted: 2019-05-24
• Study Start: 2020-09-14
• Primary Completion: 2024-05-23
• Study Completion: 2024-05-23
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-19
• Last Update Posted: 2025-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• First onset of an optic neuritis lasting for less than 1 month
• With a brain MRI that does not meet the MS criteria

Exclusion Criteria

• Contra-indication to MRI
• Pregnant or lactating woman
• History of known ipsilateral optic neuritis
• Ophthalmologic comorbidity in the ipsilateral eye that may interfere with the interpretation of the examinations

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual acuity (ETDRS scale)	1 year	Evolution over 1 year of the ophthalmological parameters of patients treated for an episode of optic neuritis not related to multiple sclerosis or a clinically isolated syndrome
Thickness of the layers of the retina with Optical Coherent Tomography(OCT),	1 year
Standard Humphrey Visual Field Test	1 year

Trial Locations

Locations (1)

Fondation A. de Rothschild; 🇫🇷 Paris, France